PMID: 9188586Jul 1, 1997Paper

Adenovirus vector-infected cells can escape adenovirus antigen-specific cytotoxic T-lymphocyte killing in vivo

Journal of Virology
S C WadsworthJ M Kaplan

Abstract

The recent findings that prolonged expression of certain adenovirus (Ad) vector-encoded proteins, including human alpha1-antitrypsin (huAAT), mouse erythropoietin (EPO), and human factor IX, can be achieved in animals that do not mount an immune response to the reporter protein were obtained with mouse strains which have been shown to be capable of mounting a cellular immune response against Ad vector antigens. This suggests either that Ad vectors expressing nonimmunogenic transgenes fail to elicit a cellular immune response or that an Ad-specific cellular immune response does develop but is ineffective against cells expressing nonimmunogenic transgenes. Here we demonstrate that an Ad vector expressing huAAT administered by intravenous injection does stimulate an Ad-specific cellular immune response but that this response fails to abolish vector-directed gene expression in vivo. Moreover, expression of huAAT remained stable in animals stimulated by concurrent and multiple administrations of different Ad vectors or viruses. We also demonstrate prolonged expression of huAAT in CD1 mice transgenic for the huAAT gene, indicating that long-term expression is not restricted to C57BL/6 mice. These results demonstrate that under some c...Continue Reading

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Citations

Dec 8, 2007·The Journal of Gene Medicine·Ping ChenJoseph T Bruder
Apr 8, 2009·Expert Review of Vaccines·De-chu C TangKent R Van Kampen
Sep 23, 2003·Arteriosclerosis, Thrombosis, and Vascular Biology·Zvonimir S KatusicKarl A Nath
Mar 5, 2013·The Journal of Clinical Investigation·Gerald WillimskyThomas Blankenstein
Oct 30, 2004·The Journal of Gene Medicine·Gunhild M MaelandsmoRobin J Parks
Oct 27, 1999·Proceedings of the National Academy of Sciences of the United States of America·N MorralA L Beaudet
Jul 29, 1998·Human Gene Therapy·C A SmithG R Kitchingman
Nov 18, 2000·Molecular Therapy : the Journal of the American Society of Gene Therapy·A ScariaS C Wadsworth
Apr 26, 2001·Molecular Therapy : the Journal of the American Society of Gene Therapy·C SoudaisE J Kremer
Aug 16, 2002·Transplant Immunology·D ChenJ S Bromberg
Oct 23, 1997·American Journal of Human Genetics·K F Kozarsky, L A Couture

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