Adenovirus vector vaccination induces expansion of memory CD4 T cells with a mucosal homing phenotype that are readily susceptible to HIV-1.

Proceedings of the National Academy of Sciences of the United States of America
Adel BenlahrechSteven Patterson

Abstract

In the recently halted HIV type 1 (HIV-1) vaccine STEP trial, individuals that were seropositive for adenovirus serotype 5 (Ad5) showed increased rates of HIV-1 infection on vaccination with an Ad5 vaccine. We propose that this was due to activation and expansion of Ad5-specific mucosal-homing memory CD4 T cells. To test this hypothesis, Ad5 and Ad11 antibody titers were measured in 20 healthy volunteers. Dendritic cells (DCs) from these individuals were pulsed with replication defective Ad5 or Ad11 and co-cultured with autologous lymphocytes. Cytokine profiles, proliferative capacity, mucosal migration potential, and susceptibility to HIV infection of the adenovirus-stimulated memory CD4 T cells were measured. Stimulation of T cells from healthy Ad5-seropositive but Ad11-seronegative individuals with Ad5, or serologically distinct Ad11 vectors induced preferential expansion of adenovirus memory CD4 T cells expressing alpha(4)beta(7) integrins and CCR9, indicating a mucosal-homing phenotype. CD4 T-cell proliferation and IFN-gamma production in response to Ad stimulation correlated with Ad5 antibody titers. However, Ad5 serostatus did not correlate with total cytokine production upon challenge with Ad5 or Ad11. Expanded Ad5 and ...Continue Reading

References

Oct 1, 1995·Seminars in Immunology·S K Shaw, M B Brenner
Mar 4, 1997·Proceedings of the National Academy of Sciences of the United States of America·C C BleulC R Mackay
Jun 8, 1999·Annual Review of Immunology·E A BergerJ M Farber
Sep 22, 1999·Gene Therapy·N ChirmuleJ Wilson
Jul 23, 2002·Human Gene Therapy·Melanie OlivePhyllis Flomenberg
Oct 9, 2002·Journal of Virology·C T GarnettLinda R Gooding
Jan 30, 2004·Annual Review of Medicine·John W Shiver, Emilio A Emini
Feb 8, 2006·Molecular Therapy : the Journal of the American Society of Gene Therapy·Nelson DiPaoloAndré Lieber
Feb 13, 2007·Immunological Reviews·Bengt Johansson-Lindbom, William W Agace
Aug 19, 2007·The Journal of General Virology·David OnionVivien Mautner
Jan 16, 2008·The Journal of Experimental Medicine·Rafick-Pierre Sekaly
Mar 8, 2008·Expert Review of Vaccines·Shan Lu
Nov 18, 2008·Lancet·M Juliana McElrathUNKNOWN Step Study Protocol Team

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Citations

Dec 29, 2010·Current HIV/AIDS Reports·Paul R Gorry, Petronela Ancuta
Nov 16, 2012·Proceedings of the National Academy of Sciences of the United States of America·Daniel E ZakM Juliana McElrath
Oct 28, 2010·Current Opinion in HIV and AIDS·Dan H Barouch
Mar 3, 2012·AIDS·Sanjay SwaminathanAnthony D Kelleher
Mar 26, 2011·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Jonathan D FuchsSusan P Buchbinder
Nov 13, 2012·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Xiaojie HuangHao Wu
Jul 22, 2011·Journal of Virology·Matthieu PerreauGiuseppe Pantaleo
Jul 20, 2012·Journal of Virology·Matthias TenbuschKlaus Uberla
Jul 9, 2011·The Journal of Clinical Investigation·Swantje I HammerschmidtReinhold Förster
Oct 19, 2011·The Journal of Clinical Investigation·Alexandra M OrtizGuido Silvestri
Oct 8, 2011·PloS One·Soumitra RoyJames M Wilson
Nov 3, 2012·PloS One·Adel BenlahrechSteven Patterson
Aug 31, 2011·F1000 Medicine Reports·Gene M Shearer, Adriano Boasso
May 14, 2014·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·A Saez-CirionM Müller-Trutwin
Mar 4, 2014·Human Gene Therapy·Dragomira MajhenJerome Custers
Oct 29, 2014·Proceedings of the National Academy of Sciences of the United States of America·George K LewisRobert C Gallo
Oct 30, 2014·AIDS Research and Human Retroviruses·Jordan PolesCatarina E Hioe
Jan 28, 2016·Expert Review of Vaccines·Haitao HuSilvia Ratto-Kim
Nov 26, 2010·Expert Review of Vaccines·Damien Z Soghoian, Hendrik Streeck
Oct 30, 2015·Expert Review of Vaccines·Sayuri Seki, Tetsuro Matano
Aug 21, 2015·Expert Review of Vaccines·Sarah C Gilbert
Sep 2, 2015·Expert Review of Vaccines·Franck Jd MennechetEric J Kremer
Jul 14, 2010·Expert Opinion on Biological Therapy·Mingke Yu, Michael Vajdy
Dec 23, 2014·Expert Opinion on Biological Therapy·Mohan Babu Appaiahgari, Sudhanshu Vrati
Sep 6, 2011·Drug Discovery Today·Chintan ChhatbarSunit Kumar Singh
Jun 18, 2011·Biochimica Et Biophysica Acta·Ying Poi Liu, Ben Berkhout

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