Adenovirus Viremia in Adult CD34(+) Selected Hematopoietic Cell Transplant Recipients: Low Incidence and High Clinical Impact

Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation
Yeon Joo LeeGenovefa Papanicolaou

Abstract

Adenovirus (ADV) infections after hematopoietic cell transplantation (HCT) range in severity from self-limited to fatal. We have previously reported high mortality rates in CD34(+) selected T cell-depleted (TCD) HCT recipients using symptomatic testing and culture methods for ADV detection. We report rates and outcomes of ADV viremia in 215 adult recipients of TCD HCT using the CliniMACS CD34(+) selection system. This was a prospective observational study of adults transplanted from March 21, 2012 through November 30, 2014 at Memorial Sloan-Kettering Cancer Center. TCD was performed using CliniMACS CD34(+) cell selection. Patients were monitored for ADV by whole blood PCR assay from +14 to +100 days post-transplant. ADV viremia was defined as ≥1 PCR above the lower limit of quantitation. ADV disease was defined per European Group for Blood and Marrow Transplantation guidelines. Treatment for ADV was at the clinician's discretion. Competing risk regression analyses were used to identify predictors for ADV viremia and overall survival. The median age was 55 years (range, 22 to 72); 215 patients underwent TCD. All patients received myeloablative conditioning. Eighteen patients (8% of cohort) had ADV viremia at a median onset of 57...Continue Reading

References

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Oct 25, 2012·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Yeon Joo LeeGenovefa A Papanicolaou
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Citations

Jun 10, 2016·Journal of Clinical Microbiology·N Esther Babady
Jul 1, 2017·Current Opinion in Infectious Diseases·Yeon Joo LeeGenovefa A Papanicolaou
Mar 12, 2019·Frontiers in Microbiology·Karin KosulinThomas Lion
Sep 2, 2020·Infection & chemotherapy·Shuk Ying ChanYeon Joo Lee
May 25, 2021·Gastroenterology Clinics of North America·Lemuel R Non, Dilek Ince

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