PMID: 41622Jan 1, 1979

Adenylate cyclase and guanylate cyclase activity in the isolated kidney glomerulus of the rat

Comptes rendus des séances de la Société de biologie et de ses filiales
J D SraerJ Sraer


Isolated rat renal glomeruli contain an adenylate cyclase system and guanylate cyclase system. Adenylate cyclase was strikingly activated by purified parathyroid hormone, epinephrine, prostaglandin I2 and histamine. The demonstration of PTH activated adenylate cyclase in glomeruli raises the possibility of a role of this hormone in regulation of glomerular filtration rate. Guanylate cyclase was strikingly activated by CA2+, nitrate derivatives such as sodium nitroprusside. Its role remained still unknown.

Related Concepts

Histamine Measurement
PTH protein, human
Sodium Nitroprusside
Parathyroid Diseases
Recombinant parathyroid hormone
Parathyroid Hormone [EPC]
Guanylate Cyclase Activity

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