Adenylyl cyclase 6 in acid-base balance - adding complexity

Clinical Science
Jakob Voelkl, Florian Lang

Abstract

Systemic acid-base balance is tightly controlled within a narrow range of pH. Disturbances in systemic acid-base homeostasis are associated with diverse detrimental effects. The kidney is a key regulator of acid-base balance, capable of excreting HCO3- or H+, and chronic kidney disease invariably leads to acidosis. However, the regulatory pathways underlying the fine-tuned acid-base sensing and regulatory mechanisms are still incompletely understood. In the article published recently in Clinical Science (vol 132 (16) 1779-1796), Poulson and colleagues investigated the role of adenylyl cyclase 6 (AC6) in acid-base homeostasis. They uncovered a complex role of AC6, specifically affecting acid-base balance during HCO3- load, which causes pronounced alkalosis in AC6-deficient mice. However, the phenotype of AC6-deficient mice appears much more complex, involving systemic effects associated with increased energy expenditure. These observations remind us that there is much to be learned about the intricate signaling pathways involved in renal control of acid-base balance and the complex ramifications of acid-base regulation.

References

Dec 1, 1981·Pflügers Archiv : European journal of physiology·T H SteeleJ L Underwood
Nov 1, 1995·The Journal of Clinical Investigation·O W MoeY Yamaji
Jan 12, 1996·Molecular and Cellular Biochemistry·M Marcos MoralesA Gil Lopes
Mar 30, 2004·Genesis : the Journal of Genetics and Development·Maxime BouchardMeinrad Busslinger
Apr 6, 2007·American Journal of Physiology. Renal Physiology·Hetal S KocinskyPeter S Aronson
Mar 12, 2009·Pflügers Archiv : European journal of physiology·Carsten A WagnerNilufar Mohebbi
Jul 18, 2009·Journal of the American Society of Nephrology : JASN·Ione de Brito-AshurstMuhammad M Yaqoob
Jan 8, 2010·American Journal of Physiology. Renal Physiology·Teodor G PăunescuDennis Brown
Aug 25, 2010·The Journal of Pharmacology and Experimental Therapeutics·Gary J HodgesRoss D Feldman
Sep 25, 2010·Journal of the American Society of Nephrology : JASN·Timo RiegVolker Vallon
Nov 26, 2011·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Carsten A WagnerJohn P Geibel
Nov 26, 2011·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Ioana AlesutanFlorian Lang
Mar 1, 2012·Journal of the American Society of Nephrology : JASN·Dennis Brown, Carsten A Wagner
Mar 20, 2013·Molecular Aspects of Medicine·Michael F RomeroWalter F Boron
May 24, 2014·Journal of the American Society of Nephrology : JASN·Robert A FentonTimo Rieg
Oct 9, 2014·The New England Journal of Medicine·Kenrick BerendRijk O B Gans
Nov 8, 2014·Nephron. Physiology·Carsten A Wagner
Nov 28, 2014·Comprehensive Physiology·Ira Kurtz
Jan 30, 2015·Clinical Journal of the American Society of Nephrology : CJASN·Ankita RoyNúria M Pastor-Soler
Aug 27, 2015·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Christina B LeibrockFlorian Lang
Nov 26, 2015·Clinical Journal of the American Society of Nephrology : CJASN·L Lee HammKathleen S Hering-Smith
Feb 25, 2017·Kidney Diseases·Julian L Seifter, Hsin-Yun Chang
Oct 23, 2017·Kidney International·Ralph KettritzFriedrich C Luft
Jun 27, 2018·Clinical Science·Søren Brandt PoulsenTimo Rieg

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Clinical Nephrology
M Martinez-Maldonado, R Sanchez-Montserrat
Monatsschrift Kinderheilkunde : Organ der Deutschen Gesellschaft für Kinderheilkunde
W DROESE
Contributions to Nephrology
N A KurtzmanC Westenfelder
© 2022 Meta ULC. All rights reserved