Adenylyl cyclase type VI corrects cardiac sarcoplasmic reticulum calcium uptake defects in cardiomyopathy

American Journal of Physiology. Heart and Circulatory Physiology
Tong TangH Kirk Hammond

Abstract

Calcium malfunction plays a central role in heart failure. Here, we provide evidence that adenylyl cyclase type VI restores sarco(endo)plasmic reticulum 2a (SERCA2a) affinity for calcium and maximum velocity of cardiac calcium uptake by sarcoplasmic reticulum in murine dilated cardiomyopathy. Restoration of normal SERCA2a affinity for calcium is associated not only with decreased phospholamban protein expression but also with increased phospholamban phosphorylation by PKA activation. The ratio of phosphorylated ryanodine receptor 2 (RyR2) to RyR2 protein was increased, but the amount of phosphorylated RyR2 was unaffected. These data provide a possible mechanism by which adenylyl cyclase type VI (in contrast to other signaling elements associated with increased cAMP generation) has a salutary effect in the failing heart.

References

Jul 22, 1982·The New England Journal of Medicine·M R BristowE B Stinson
Jan 1, 1996·Annual Review of Pharmacology and Toxicology·R K SunaharaA G Gilman
Jul 22, 1997·Proceedings of the National Academy of Sciences of the United States of America·D D D'AngeloG W Dorn
Mar 14, 1998·Proceedings of the National Academy of Sciences of the United States of America·M GaoH K Hammond
Apr 13, 1999·Journal of Molecular and Cellular Cardiology·R H SchwingerE Erdmann
May 26, 1999·Proceedings of the National Academy of Sciences of the United States of America·G W DornS B Liggett
Jul 15, 1999·Journal of Molecular and Cellular Cardiology·A YataniG W Dorn
Feb 15, 2001·Circulation·M Bristow
Jan 24, 2002·Nature·Donald M Bers
May 9, 2002·Circulation·David M RothH Kirk Hammond
Jan 2, 2003·The Journal of Physiology·Ivar SjaastadOle M Sejersted
Mar 1, 2003·Science·Joachim P SchmittChristine E Seidman
Mar 8, 2003·Circulation Research·Steven R Houser, Kenneth B Margulies
May 2, 2003·Nature Medicine·Kenneth R ChienMasahiko Hoshijima
Jul 3, 2003·Nature Reviews. Molecular Cell Biology·David H MacLennan, Evangelia G Kranias
Nov 15, 2003·Circulation Research·Martin J LohseThomas Eschenhagen
Feb 18, 2004·Nature Medicine·Julian C BrazJeffery D Molkentin

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Citations

Jun 13, 2012·Wiener medizinische Wochenschrift·Hannes Reuter, Robert H G Schwinger
Apr 27, 2012·Gene Therapy·T TangH Kirk Hammond
Oct 8, 2008·The Journal of Biological Chemistry·Mei Hua GaoH Kirk Hammond
Jun 22, 2010·American Journal of Physiology. Heart and Circulatory Physiology·Aziz GuellichDorothy E Vatner
Oct 23, 2013·PloS One·Mei Hua GaoH Kirk Hammond
Dec 25, 2012·Translational Research : the Journal of Laboratory and Clinical Medicine·Tong Tang, H Kirk Hammond
Jan 5, 2011·Biochemical and Biophysical Research Communications·Yasuo SuganoH Kirk Hammond
Oct 19, 2013·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Riris I JenieHiroshi Itoh
Oct 25, 2008·Biochemical and Biophysical Research Communications·Tong TangH Kirk Hammond
Mar 11, 2006·European Journal of Pharmacology·Michael A Beazely, Val J Watts
Apr 17, 2013·Journal of Molecular and Cellular Cardiology·Tong TangH Kirk Hammond
Apr 12, 2008·Journal of the American College of Cardiology·N Chin LaiH Kirk Hammond
Apr 30, 2011·Journal of the American College of Cardiology·Tong TangN Chin Lai
Feb 25, 2017·Stem Cells·Caressa ChenIoannis Karakikes
Oct 14, 2006·Circulation Research·Rodolphe FischmeisterGrégoire Vandecasteele
Jan 4, 2019·Cardiovascular Research·Nathalie MougenotLarissa Lipskaia
Mar 23, 2017·Human Gene Therapy·William F Penny, H Kirk Hammond

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