Adequacy and safety of buccal misoprostol for cervical preparation prior to termination of second-trimester pregnancy

Contraception
Ashlesha PatelPlanned Parenthood Federation of America Buccal Misoprostol Waiver Group

Abstract

The objective of this retrospective, descriptive study is to assess the adequacy and safety of buccal misoprostol with and without laminaria for cervical preparation prior to second-trimester abortion. We analyzed Planned Parenthood Federation of America data from 2,218 elective dilation and evacuation (D&E) procedures conducted on women at 12 to 23 6/7 weeks of gestation from April 2002 to March 2003. Each woman received 400, 600 or 800 microg of buccal misoprostol with or without laminaria for preprocedural cervical preparation. Of the patients, 62% received 400 mug, 32% received 600 microg and 6% received 800 microg of buccal misoprostol; 42.8% had laminaria inserted for phased cervical preparation. The adequacy of cervical dilation was 88.7%. The D&E procedure was completed during a single surgical procedure for 99.8%. The overall adverse event rate was 19.39 per 1,000 women, with a rate of 4.51 per 1,000 women for serious adverse events. This descriptive study suggests that use of buccal misoprostol with or without laminaria is effective and safe. If buccal misoprostol eliminates or reduces the need for phased, multiday laminaria 1-3 days prior to the surgical procedure, then its use may offer service advantages such as re...Continue Reading

Associated Clinical Trials

Mar 26, 2013·Christy Boraas, Christy Boraas

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Citations

May 2, 2009·Clinical Obstetrics and Gynecology·Jennifer L Hayes, Michelle C Fox
Dec 12, 2012·Contraception·Jennifer Kerns, Jody Steinauer
Nov 5, 2013·Journal of Minimally Invasive Gynecology·Anna Lawin-O'BrienFunlayo Odejinmi
Dec 20, 2015·Contraception·Rebecca H Allen, Alisa B Goldberg
Mar 15, 2011·Contraception·Sharon L AchillesUNKNOWN Society of Family Planning
Jan 28, 2010·Contraception·Hemang B PanchalAshlesha Patel
Sep 17, 2008·Reproductive Health Matters·Patricia A Lohr
Mar 18, 2008·Contraception·Sara NewmannUNKNOWN Society of Family Planning
Dec 7, 2007·Contraception·Michelle C FoxUNKNOWN Society of Family Planning
Jul 28, 2007·Contraception·Rebecca H AllenUNKNOWN Board of Society of Family Planning
Feb 24, 2007·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·M GüneyT Mungan
Mar 26, 2009·American Journal of Obstetrics and Gynecology·Cassing Hammond
Nov 3, 2016·Current Opinion in Obstetrics & Gynecology·Kate A Shaw, Klaira Lerma
Sep 17, 2008·Reproductive Health Matters·Daniel GrossmanPaul Blumenthal
Apr 24, 2018·Obstetrics and Gynecology
Aug 6, 2010·The Cochrane Database of Systematic Reviews·Sara J NewmannEleanor A Drey
Apr 21, 2019·Advances in Therapy·Jessika A Ralph, Lee P Shulman
Nov 14, 2006·Current Opinion in Obstetrics & Gynecology
Apr 30, 2020·Journal of Obstetrics and Gynaecology Canada : JOGC = Journal D'obstétrique Et Gynécologie Du Canada : JOGC·Gabriel LevinAmihai Rottenstreich

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