PMID: 3772524Oct 1, 1986Paper

Adequacy of chemically defined, water-soluble diet for germfree BALB/c mice through successive generations and litters

The Journal of Nutrition
J R PleasantsB S Wostmann

Abstract

To determine dietary adequacy, germfree BALB/cAnN mice were fed ad libitum an ultrafiltered solution of chemically defined, water-soluble, low-molecular-weight nutrients. They received a measured daily supplement of membrane-filtered, distillation-purified soy oil containing vitamins A, D, E and K. Mice were kept on ash-free filter paper bedding, which they freely consumed. On this regimen, germfree BALB/c mice reproduced through nine generations, and through eight litters in one generation. Average number born per litter was 4.1, compared with 5.1 in control BALB/c mice, which had a conventional microflora and were fed a natural ingredient diet. From 21 to 32 d of age, the experimental mice gained more slowly than controls. After 32 d, experimental mice gained more rapidly than controls; their weights tended to be lower than controls at 45 d and equal to controls at 56 d. Intake-limiting effects of the diet appeared responsible for reduced growth rates and litter size. Experimental females showed a low incidence of deaths from cecal volvulus. Experimental males experienced a high incidence of deaths from colonic impaction of cecally-formed trichobezoars; this site of formation appeared to be unique to BALB/c males on the exper...Continue Reading

Citations

Jul 16, 2014·The ISME Journal·Marilou P Sison-MangusDieter Ebert
Jun 15, 2005·Scandinavian Journal of Immunology·H Tlaskalova-HogenovaM Kverka
Oct 4, 2017·Science·Jeffrey J BunkerAlbert Bendelac
Jan 13, 1997·Biochemical and Biophysical Research Communications·T Marks, W R Farkas
Aug 25, 1989·Science·J KillgoreR B Rucker

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