Adequacy of powered vs manual bone marrow biopsy specimens: a retrospective review of sequential marrow aspirates and biopsies in 68 patients

American Journal of Clinical Pathology
Douglas W LynchNancy S Rosenthal

Abstract

To evaluate the quality and quantity of the bone marrow aspirates and biopsy specimens obtained with a powered system in comparison with the standard manual method. The Pathology Laboratory Information System was reviewed for patients who had previously undergone bone marrow biopsies performed by both the OnControl Bone Marrow System and the manual method. A total of 136 cases (68 patients) were reviewed for adequacy and compared using an unpaired t test. The core biopsy specimens obtained by the OnControl system were significantly longer compared with those obtained by the manual system (16.9 vs 14.4 mm, P = .0036). However, the core biopsy specimens obtained by the manual method had on average more evaluable marrow elements (66% vs 40%, P < .0001), and the manual method was superior in 46 of the 68 cases when the length of evaluable marrow was calculated (9.7 vs 7 mm, P = .0049). Our findings show that longer core biopsy specimens are obtained by the OnControl Bone Marrow system but that the manual method is still superior when the percentage and length of evaluable bone marrow are analyzed.

References

Dec 1, 1992·Journal of Clinical Pathology·P W BishopM Harris
Sep 29, 2001·Journal of Clinical Pathology·B J Bain
Apr 21, 2010·Journal of Clinical Pathology·Ronan T SwordsAndrew J Brenner
May 25, 2011·Journal of Clinical Pathology·Ronan T SwordsAndrew J Brenner
Apr 13, 2013·Cardiovascular and Interventional Radiology·Dirk SchnapauffBernhard Gebauer
Jul 3, 2013·Archives of Pathology & Laboratory Medicine·Alyaa Al-IbraheemiAndy N D Nguyen

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Citations

Mar 10, 2016·AJR. American Journal of Roentgenology·Micah G CohenJim S Wu
Dec 9, 2017·Skeletal Radiology·I-Yuan Joseph ChangNaveen Subhas
Feb 20, 2019·International Journal of Laboratory Hematology·Kathryn M ForwoodPhilip J Crispin
Oct 12, 2018·American Journal of Clinical Pathology·Jonathan R BrestoffAnjum Hassan

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