Adequacy of Samples Obtained by Endobronchial Ultrasound with Transbronchial Needle Aspiration for Molecular Analysis in Patients with Non-Small Cell Lung Cancer. Systematic Review and Meta-Analysis

Annals of the American Thoracic Society
Gonzalo LabarcaSebastián Fernández-Bussy

Abstract

Endobronchial ultrasound and transbronchial needle aspiration (EBUS-TBNA) are commonly used for the diagnosis and mediastinal staging of lung cancer. Molecular markers are becoming increasingly important in patients with lung cancer to define targetable mutations suitable for personalized therapy, such as epidermal growth factor receptor (EGFR), anaplastic lymphoma kinase (ALK), reactive oxygen species proto-oncogene (ROS1), and programmed death-ligand 1 (PD-L1). To evaluate the adequacy of EBUS-TBNA-derived tissue for molecular analysis. We searched the MEDLINE, LILACS, www.clinicaltrials.gov , and Epistemonikos databases through January 2018. Two independent reviewers performed the data search, quality assessment, and data extraction. We included both prospective and retrospective studies; risk of bias was evaluated using the ROBINS-I tool. The primary outcome was the proportion of adequate samples obtained by EBUS-TBNA for molecular analysis. Data were pooled by using a binary random effects model. Finally, evidence was rated by using the GRADE (Grading of Recommendations Assessment, Development and Evaluation) approach. A total of 33 studies including 2,698 participants were analyzed. In 28 studies that evaluated EBUS-TBNA ...Continue Reading

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Citations

May 21, 2019·Journal of Bronchology & Interventional Pulmonology·Sebastian Fernandez-BussyHiren J Mehta
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Jun 19, 2021·The European Respiratory Journal·Jing ZhangYe Fan

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Methods Mentioned

BETA
biopsies
PCR
biopsy

Software Mentioned

GRADEpro
Evidence Prime
OpenMeta [ Analyst

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