Adequate anti-infective treatment : Importance of individual dosing and application

Der Anaesthesist
A BrinkmannO R Frey

Abstract

Sepsis-induced changes in pharmacokinetic parameters are a well-known problem in intensive care medicine. Dosing of antibiotics in this setting is therefore challenging. Alterations to the substance-specific kinetics of anti-infective substances have an effect on the distribution and excretion processes in the body. Increased clearance and an increased distribution volume (Vd) and particularly compromized organ function with reduced antibiotic elimination are often encountered in patients with sepsis. Renal replacement treatment, which is frequently used in intensive care medicine, represents a substantial intervention in this system. Current international guidelines recommend individualized dosing strategies and adaptation of doses according to measured serum levels and pharmacokinetic/pharmacodynamic (PK/PD) parameters as concepts to optimize anti-infective therapy in the critically ill. Likewise, the recommendation to adjust the administration form of beta-lactam antibiotics to prolonged or continuous infusion can be found increasingly more often in the literature. This article reviews the background of the individual dosing in intensive care patients and their applicability to the clinical routine.

References

Dec 5, 2006·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Paul G AmbroseGeorge L Drusano
Dec 26, 2006·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Isabel SprietLudo Willems
Jan 6, 2007·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Thomas P LodiseGeorge L Drusano
May 18, 2011·Antimicrobial Agents and Chemotherapy·G L DrusanoA Louie
Jul 3, 2013·Journal of Clinical Pharmacy and Therapeutics·C LichtensternM A Weigand
Jan 17, 2014·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Jason A RobertsUNKNOWN DALI Study
Jan 21, 2014·The Journal of Antimicrobial Chemotherapy·Gloria WongJason A Roberts
Apr 29, 2014·The Lancet Infectious Diseases·Jason A RobertsUNKNOWN International Society of Anti-Infective Pharmacology and the Pharmacokinetics and Pharmacodynamics Study Group of the Europe
Jan 31, 2015·The International Journal of Artificial Organs·Anka C RoehrAlexander Brinkmann
Mar 31, 2015·Der Anaesthesist·Erik Michael, Detlef Kindgen-Milles
Jul 5, 2015·International Journal of Antimicrobial Agents·Timothy HanrahanJason A Roberts
Dec 26, 2015·The Journal of Antimicrobial Chemotherapy·Abdulaziz S AlobaidJason A Roberts
Mar 15, 2016·American Journal of Respiratory and Critical Care Medicine·Jason A RobertsJeffrey Lipman
Sep 15, 2016·Medizinische Klinik, Intensivmedizin und Notfallmedizin·A BrinkmannO R Frey
Oct 1, 2016·Intensive Care Medicine·UNKNOWN SepNet Critical Care Trials Group
Oct 26, 2016·Critical Care : the Official Journal of the Critical Care Forum·Ute BlassmannVolker Huge
Dec 29, 2016·Current Opinion in Infectious Diseases·Mohd H Abdul-AzizJason A Roberts
Jan 6, 2017·Antimicrobial Agents and Chemotherapy·Abdulaziz S AlobaidJason A Roberts
Jan 19, 2017·Critical Care Medicine·Jason A RobertsJeffrey Lipman
Jan 20, 2017·Intensive Care Medicine·Andrew RhodesR Phillip Dellinger
Apr 8, 2017·Intensive Care Medicine·Jason A RobertsJeffrey Lipman
May 10, 2017·Medizinische Klinik, Intensivmedizin und Notfallmedizin·J T KielsteinS Scherneck
May 26, 2017·The Journal of Antimicrobial Chemotherapy·Max TaubertMichael Zoller
Jun 3, 2017·Der Internist·M W PletzT Welte
Jul 18, 2017·International Journal of Antimicrobial Agents·Sebastian G WichaMagnus Kaffarnik
Oct 6, 2017·Der Anaesthesist·D C RichterChristoph Lichtenstern
Nov 2, 2017·The Journal of Antimicrobial Chemotherapy·Sahand ImaniIndy Sandaradura

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Citations

Dec 13, 2019·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·Claude MabilatIsabelle Caniaux
Feb 3, 2021·Medizinische Klinik, Intensivmedizin und Notfallmedizin·H HilgarthC König

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