PMID: 9543371Apr 16, 1998Paper

Adequate clinical control of congenital nephrotic syndrome by enalapril

Pediatric Nephrology : Journal of the International Pediatric Nephrology Association
S GuezB M Assael

Abstract

The combination of captopril and indomethacin has been shown to control nephrotic proteinuria in an infant with congenital nephrotic syndrome of the Finnish type. We report the satisfactory control of congenital nephrotic syndrome by enalapril, maintaining normal serum albumin levels without albumin infusions. The haplotype data of our patient were consistent with the diagnosis of a Finnish-type nephrotic syndrome. After 21 months, during which daily infusions of albumin allowed partial control of the symptoms, captopril treatment was started. No adverse effects were noted. Serum creatinine levels remained normal. Within 8 weeks, albumin infusions were completely stopped. After 1 month the treatment was changed to a single dose of enalapril (0.8 mg/kg per day). During the next 15 months, the serum protein concentration was maintained around 6.5-7 g/dl, although proteinuria persisted (0.3-0.5 g/day). Weight and length gain are now satisfactory. We conclude that enalapril may be safely used in infants with severe forms of congenital nephrotic syndrome and might allow the avoidance of aggressive treatments for prolonged periods.

Citations

Jun 21, 2005·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Rajasree Sreedharan, Detlef Bockenhauer
May 17, 2006·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Kevin V Lemley
Jun 15, 2006·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Zhuwen YiXiao-Jie He
Aug 21, 2013·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·William WongTonya Kara
Aug 10, 2006·Néphrologie & thérapeutique·Patrick Niaudet
Jan 17, 2009·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Willem ProesmansKoenraad Devriendt
Jun 23, 2009·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Neveen Soliman
Jul 24, 2010·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Nathalie Godefroid, Karin Dahan
Sep 22, 1999·Archives of Disease in Childhood·P A HeatonW Wong
Feb 10, 2007·Kidney International·A KitamuraK Iijima
Dec 18, 2001·Prenatal Diagnosis·D Wellesley, D T Howe
Nov 7, 2007·Journal of Hypertension·Giacomo D SimonettiMario G Bianchetti
Mar 20, 2003·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Abhay N VatsMichael Mauer
Dec 4, 2001·Annals of Medicine·H JalankoC Holmberg
Apr 11, 2003·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Larisa KovacevicSusan P A Rigden
Sep 29, 2021·Clinical and Experimental Nephrology·Miki MurakoshiKazumoto Iijima

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