PMID: 9529096Apr 7, 1998Paper

Adequate expression of protective immunity in the absence of granuloma formation in Mycobacterium tuberculosis-infected mice with a disruption in the intracellular adhesion molecule 1 gene

Infection and Immunity
C M JohnsonI M Orme

Abstract

It remains unknown whether the expression of cell-mediated protective immunity and the capacity to mount a delayed-type hypersensitivity (DTH) reaction in tuberculosis infection represent two manifestations of a basic response or are dissociable events. In this study, we present data in favor of the latter hypothesis, by showing that tuberculosis infection in the lungs of mice possessing only a truncated form of intracellular adhesion molecule 1 due to gene disruption was still adequately controlled by the expression of protective immunity in the absence of any sustained influx of macrophages and the lack of formation of appreciable granulomas. These animals also had no detectable DTH response to mycobacterial proteins in the footpad assay, indicating that the accumulation of blood-borne macrophages at sites of mycobacterial infection or antigen deposition is not essential to control of the infection. These data support the hypothesis that the DTH component of the cellular response is not protective but contributes by walling off the sites of infection to prevent dissemination and reactivation disease.

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Citations

Apr 26, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·C G FengA G Bean
Jul 6, 2000·Laboratory Investigation; a Journal of Technical Methods and Pathology·M JacobsB Ryffel
Jul 18, 2002·American Journal of Respiratory and Critical Care Medicine·Hyung-Seok ChoiEdward D Chan
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Apr 25, 2006·Immunology·Manuela Flórido, Rui Appelberg
Mar 7, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kamlesh BhattPadmini Salgame
Nov 5, 1999·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·J K ActorR L Hunter
Nov 22, 2005·Drugs·Ian M Orme
Apr 6, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Shamik GhoshSamuel M Behar
Aug 18, 2000·Immunology and Cell Biology·B M Saunders, A M Cooper
Mar 13, 2001·Annual Review of Immunology·J L Flynn, J Chan
May 1, 2013·Infection and Immunity·Sandro Silva-GomesMaria Salomé Gomes
Apr 20, 2001·Scandinavian Journal of Immunology·J K ActorC Jagannath
Mar 17, 1999·FEMS Immunology and Medical Microbiology·S Ehlers
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Oct 23, 2010·Journal of the American Chemical Society·Yoann RomboutsYann Guérardel

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