Adequate preoperative staging rarely leads to a change of intraoperative strategy in patients undergoing surgery for colorectal cancer liver metastases

Surgery
Dietmar TamandlT Gruenberger

Abstract

Diagnostic tools used prior to hepatic surgery have significantly advanced during the last decade. We investigated the value of preoperative staging on detection of additional resectable hepatic lesions in metastatic colorectal cancer patients. One hundred ninety-four consecutive resections for colorectal liver metastases between January 2002 and December 2005 were prospectively analyzed. Data on imaging (multidetector computed tomography [MDCT] and magnetic resonance imaging [MRI]) were compared to intraoperative findings by intraoperative sonography and bimanual palpation together with histopathological examination. Univariate and multivariate analysis of factors influencing recurrence was performed. In 16 (8.2%) resections, additional lesions were detected intraoperatively. In 11 cases (5.7%), these were small (<1 cm) and subcapsular. Detection of additional tumors was associated with shorter median recurrence free survival (5.4 vs. 13.4 months; P < .001) even though all lesions were resected and risk of recurrence was stratified by the Fong score. Patients treated with neoadjuvant chemotherapy did not generally have an increased risk of additional tumors; however, intraoperative detection of new lesions was associated with ...Continue Reading

References

May 3, 2001·Journal of the American College of Surgeons·W R JarnaginL H Blumgart
Jul 5, 2002·World Journal of Surgery·Johannes ZacherlRudolf Steininger
Dec 6, 2002·The British Journal of Radiology·V Trillet-LenoirP J Valette
Dec 22, 2004·Archives of Surgery·Stephen R GrobmyerWilliam R Jarnagin
Mar 19, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Gregory D LeonardNancy E Kemeny
Sep 13, 2005·Cancer Imaging : the Official Publication of the International Cancer Imaging Society·Subba R DigumarthySanjay Saini
Oct 19, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Vijay P KhatriJacques Belghiti
Nov 30, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Timothy AkhurstYuman Fong
Dec 22, 2005·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Zenichi MoriseKotaro Maeda
Jun 13, 2006·Cancer Imaging : the Official Publication of the International Cancer Imaging Society·J Ward
Aug 22, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Stéphane BenoistBernard Nordlinger
Oct 19, 2006·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·D TamandlT Gruenberger
Nov 7, 2006·Annals of Surgical Oncology·B WieringT J M Ruers

❮ Previous
Next ❯

Citations

Mar 19, 2011·Surgical Endoscopy·Krzysztof LeksowskiJanusz Rudzinski
Oct 2, 2012·Cancer Imaging : the Official Publication of the International Cancer Imaging Society·Wolfgang SchimaAhmed Ba-Ssalamah
Feb 9, 2012·International Journal of Surgical Oncology·Anton L GueorguievSteven C Cunningham
Jun 10, 2009·Annals of Surgical Oncology·Srinevas K ReddyBryan M Clary
Jan 10, 2013·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Reid B AdamsUNKNOWN Society for Surgery of the Alimentary Tract
Jun 2, 2012·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·V Berger-KulemannA Ba-Ssalamah
Mar 3, 2015·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Guillaume HochAhmet Ayav
Aug 30, 2016·Current Colorectal Cancer Reports·Ibrahim Nassour, Patricio M Polanco
Jun 30, 2015·International Journal of Surgery·Angélica Maria LuccheseGabriel Garcia Rolim de Moura
Sep 24, 2016·European Journal of Gastroenterology & Hepatology·Angelo PierangeloBrice Gayet
Jan 8, 2021·The Journal of Surgical Research·Takeshi AokiMasahiko Murakami
Mar 19, 2019·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·G DesolneuxS Evrard

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.