PMID: 1652269Jan 1, 1991Paper

ADH-dependent phosphoinositide signalling system and prostaglandin E production in the frog urinary bladder

Cellular Signalling
R G Parnova, D L Firsov

Abstract

Antidiuretic hormone (ADH) stimulated formation of inositol 1,4,5-trisphosphate (IP3), 1,2-diaclyglycerol (DAG) and an increase of phosphatidylinositol 4,5-biphosphate (PIP2) breakdown in the frog urinary bladder 20 s after addition. ADH also increased the prostaglandin E (PGE) secretion into serosal medium 3.5-fold and the release of arachidonic acid (AA) from 1,2-DAG, which was intensified in the presence of DAG kinase inhibitor R59022. Neomycin sulphate (10(-5) M) from the serosal side blocked ADH-stimulated PIP2 hydrolysis, IP3 production and increased the hydro-osmotic response to ADH. It also inhibited the ADH-stimulated PGE production (55%) and release of AA from 1,2-DAG. This data suggest that PIP2 breakdown is involved in the mechanism of feedback regulation of ADH action and is associated with PGE production via (i) the increase of AA release from PIP2-generated 1,2-DAG and (ii) possible activation of phospholipase A2 by IP3-induced elevation of cytosol Ca2+.

References

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Citations

Sep 5, 2003·European Journal of Pharmacology·Yoshimi TsuchiyaKazuo T Suzuki
Mar 28, 2002·Environmental Pollution·Roberta CerutiEugenio Scanziani
Aug 10, 2000·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·C L ChenR Lazzara
May 1, 1997·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·E AtzpodienS Radhofer-Welte
Jul 1, 1992·Pflügers Archiv : European journal of physiology· Natochin YuV, E I Shakhmatova
Mar 1, 1995·Cellular Signalling·A Gobbetti, M Zerani
Feb 17, 1994·Biochimica Et Biophysica Acta·D L Firsov, R G Parnova

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