DOI: 10.1101/452805Oct 25, 2018Paper

ADHD: relation between cognitive characteristics and DAT1 / DRD4 dopamine polymorphisms

BioRxiv : the Preprint Server for Biology
Maria Cristina Pinto-DussanHumberto Arboleda


Attention deficit hyperactivity disorder (ADHD) is a clinical and diagnostic heterogeneous picture. This study analyzed the association of functional polymorphisms in DAT1 VNTR 3' UTR and DRD4 VNTR Exon III candidate genes, and the neuropsychological characterization of attention and executive functions of a group of children with ADHD vs. controls. 32 patients and 51 controls were selected. The DAT1 10-repeat allele appeared more frequently in the two groups (cases: 0.93/control: 0.82), showing an OR: 2.5 (IC 95%: 0.684- 9.133; p: 0.158). In DRD4, the 4-repeat allele shows the highest occurrence (cases: 0.62/ controls: 0.60). None of the markers presented a significant association after a direct analysis, but the DRD4 7-repeat marker showed a positive risk when performing a Bayesian logistic analysis (coefficient: -1.69; OR: 5.39 CI 95%: 1.167- 40.97). On the other hand, when considering association with cognitive performance, a positive risk for processing speed and attention tasks was identified.

Related Concepts

Related Feeds

BioRxiv & MedRxiv Preprints

BioRxiv and MedRxiv are the preprint servers for biology and health sciences respectively, operated by Cold Spring Harbor Laboratory. Here are the latest preprint articles (which are not peer-reviewed) from BioRxiv and MedRxiv.

Attention Disorders

Attention is involved in all cognitive activities, and attention disorders are reported in patients with various neurological diseases. Here are the latest discoveries pertaining to attention disorders.