Oct 25, 2018

ADHD: relation between cognitive characteristics and DAT1 / DRD4 dopamine polymorphisms

BioRxiv : the Preprint Server for Biology
Maria Cristina Pinto-DussanHumberto Arboleda

Abstract

Attention deficit hyperactivity disorder (ADHD) is a clinical and diagnostic heterogeneous picture. This study analyzed the association of functional polymorphisms in DAT1 VNTR 3' UTR and DRD4 VNTR Exon III candidate genes, and the neuropsychological characterization of attention and executive functions of a group of children with ADHD vs. controls. 32 patients and 51 controls were selected. The DAT1 10-repeat allele appeared more frequently in the two groups (cases: 0.93/control: 0.82), showing an OR: 2.5 (IC 95%: 0.684- 9.133; p: 0.158). In DRD4, the 4-repeat allele shows the highest occurrence (cases: 0.62/ controls: 0.60). None of the markers presented a significant association after a direct analysis, but the DRD4 7-repeat marker showed a positive risk when performing a Bayesian logistic analysis (coefficient: -1.69; OR: 5.39 CI 95%: 1.167- 40.97). On the other hand, when considering association with cognitive performance, a positive risk for processing speed and attention tasks was identified.

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Mentioned in this Paper

Biological Markers
Gene Polymorphism
Exons
Candidate Disease Gene
DRD4
ADHD1
Executive Function
Minisatellite Repeats
Dopamine Measurement
Dopamine

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