PMID: 9529065Apr 7, 1998Paper

Adherence of Streptococcus pneumoniae to respiratory epithelial cells is inhibited by sialylated oligosaccharides

Infection and Immunity
R BarthelsonP Simon

Abstract

To study carbohydrate-mediated adherence of Streptococcus pneumoniae to the human airway, we measured binding of live S. pneumoniae organisms to a cultured cell line derived from the lining of the conjunctiva and to primary monolayers of human bronchial epithelial cells in the presence and absence of oligosaccharide inhibitors. Both encapsulated and nonencapsulated strains of S. pneumoniae grown to mid-logarithmic phase in suspension culture adhered to cultured primary respiratory epithelial cells and the conjunctival cell line. Adherence of nine clinically prevalent S. pneumoniae capsular types studied was inhibited preferentially by sialylated oligosaccharides that terminate with the disaccharide NeuAc alpha2-3(or 6)Galbeta1. Adherence of some strains also was weakly inhibited by oligosaccharides that terminate with lactosamine (Galbeta1-4GlcNAcbeta1). When sialylated oligosaccharides were covalently coupled to human serum albumin at a density of approximately 20 oligosaccharides per molecule of protein, the molar inhibitory potency of the oligosaccharide inhibitor was enhanced 500-fold. The above-mentioned experiments reveal a previously unreported dependence upon sialylated carbohydrate ligands for adherence of S. pneumonia...Continue Reading

References

Nov 1, 1991·The Annals of Otology, Rhinology, and Laryngology·D J LimL O Bakaletz
Aug 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·H C KrivanV Ginsburg
Jul 1, 1986·The Journal of Antimicrobial Chemotherapy·R Austrian
Mar 1, 1985·Reviews of Infectious Diseases·L A BurmanB Trollfors
Mar 16, 1983·Biochemical and Biophysical Research Communications·J ParkkinenT K Korhonen
Mar 1, 1984·The American Journal of Physiology·D L ColemanJ H Widdicombe
May 11, 1995·The New England Journal of Medicine·E I TuomanenH R Masure
Jul 1, 1995·Infection and Immunity·D R CundellH R Masure
Nov 1, 1994·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·J O Klein
Mar 1, 1994·The Pediatric Infectious Disease Journal·G AnianssonH Sabharwal
Dec 1, 1995·Microbiological Reviews·E AlonsoDeVelascoH Snippe
Apr 13, 1996·Lancet·D Zopf, S Roth
Dec 1, 1995·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·D CundellE I Tuomanen
Sep 1, 1997·Pediatric Research·E I Tuomanen
Sep 18, 1997·The Journal of Infectious Diseases·I Idänpään-HeikkiläE Tuomanen

❮ Previous
Next ❯

Citations

Mar 6, 2002·Clinical and Experimental Immunology·S LifshitzY Mizrachi Nebenzahl
Oct 6, 2006·Medicinal Research Reviews·Roland J Pieters
Nov 19, 2014·Future Microbiology·Stella CascioferroDomenico Schillaci
Mar 25, 2020·Chemistry & Biodiversity·Stephanie Leigh-de Rapper, Sandy F van Vuuren
Feb 18, 2011·Bioengineered Bugs·Richard J Thomas
Nov 4, 2000·Expert Opinion on Investigational Drugs·C G Kelly, J S Younson
Jul 14, 2010·Phytotherapy Research : PTR·Sanna HuttunenCarina Tikkanen-Kaukanen
Apr 26, 2006·Clinical and Experimental Immunology·D DanielyY Mizrachi Nebenzahl
Sep 3, 2016·Clinical & Translational Immunology·Nicholas J AndreasKirsty Mehring Le Doare
Jan 26, 2017·MBio·David M P De OliveiraMartina L Sanderson-Smith
Nov 30, 2019·Nature Communications·Weston KightlingerMichael C Jewett
Sep 4, 2001·Biotechnology & Genetic Engineering Reviews·C G KellyG Pozzi
Mar 30, 2006·Antimicrobial Agents and Chemotherapy·Michael P MalakhovFang Fang
Feb 4, 2011·The Journal of Biological Chemistry·David A SelaDavid A Mills
Jan 29, 2005·Chembiochem : a European Journal of Chemical Biology·Susanne M C JohanssonJan Kihlberg
Jun 22, 1999·Infection and Immunity·R P VanmaeleG D Armstrong
Aug 22, 2008·The Journal of Nutrition·Günther Boehm, Guido Moro
May 19, 2019·International Journal of Environmental Research and Public Health·Karolina KarczBarbara Królak-Olejnik
Aug 15, 2015·Toxicon : Official Journal of the International Society on Toxinology·Kwangkook LeeRongsheng Jin
Sep 24, 2005·The Journal of Nutrition·Jenni HakkarainenCarina Tikkanen-Kaukanen
Mar 31, 2018·Frontiers in Immunology·Kirsty Le DoarePia S Pannaraj
Apr 17, 2021·Scientific Reports·Heema K N VyasMartina L Sanderson-Smith
Mar 5, 2010·Acta histochemica·Haike GhazarianSteven B Oppenheimer
Jan 23, 1999·Current Opinion in Chemical Biology·C A Lingwood
Nov 5, 2011·Annals of Anatomy = Anatomischer Anzeiger : Official Organ of the Anatomische Gesellschaft·Svend KirkebyHenrik Vorum

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bacterial Pneumonia (ASM)

Bacterial pneumonia is a prevalent and costly infection that is a significant cause of morbidity and mortality in patients of all ages. Here is the latest research.

Bacterial Pneumonia

Bacterial pneumonia is a prevalent and costly infection that is a significant cause of morbidity and mortality in patients of all ages. Here is the latest research.

© 2022 Meta ULC. All rights reserved