Adherence to Allergen Subcutaneous Immunotherapy is Increased by a Shortened Build-Up Phase: A Retrospective Study

BioMed Research International
Cristiano CarusoStefania Colantuono

Abstract

Introduction. The poor long-term adherence is known to affect the efficacy of allergen immunotherapy (AIT). In the case of injection AIT (SCIT), one of the main determinants is the inconvenience for patients to undergo prolonged build-up phases. Thus, simplifying the time schedule of the induction protocol could be effective in increasing the adherence to SCIT. We backtracked the SCIT renewal orders, thanks to the cooperation of the manufacturing company, and we compared the long-term adherence of 152 patients, who were prescribed with an abbreviated build-up schedule (4 injections, allergoid) with that of 302 patients treated with the same product, but with the traditional build-up protocol (7 injections). According to the patient-named refills, those patients on the abbreviated build-up were significantly more compliant at the 2nd and 3rd year of treatment compared to the other group (p=0.0001). The drop-out rate after one year was also significantly lower between the two groups (p=0.0001). The drop-out rate after one year was also significantly lower between the two groups (p=0.0001). The drop-out rate after one year was also significantly lower between the two groups (. Abbreviating the build-up phase by reducing the number...Continue Reading

References

Dec 13, 2005·The Journal of Allergy and Clinical Immunology·Giovanni Battista PajnoGiovanni Barberio
Oct 14, 2009·Current Opinion in Allergy and Clinical Immunology·Gianenrico SennaGiovanni Passalacqua
Nov 26, 2010·The Journal of Allergy and Clinical Immunology·Cheryl S Hankin, Richard F Lockey
Dec 3, 2010·The Journal of Allergy and Clinical Immunology·Linda CoxDana Wallace
Nov 28, 2012·International Archives of Allergy and Immunology·Oliver PfaarLudger Klimek
Jan 3, 2013·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·G PassalacquaG W Canonica
Mar 29, 2013·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Tolly G EpsteinDavid I Bernstein
Apr 4, 2013·Current Opinion in Otolaryngology & Head and Neck Surgery·William R Reisacher, Jiovani M Visaya
May 9, 2013·The Journal of Allergy and Clinical Immunology·Menno A KielMaureen P M H Rutten-van Mölken
Jun 4, 2013·Current Allergy and Asthma Reports·Christopher W Calabria
Mar 13, 2014·The Journal of Allergy and Clinical Immunology. in Practice·Linda S CoxRichard Lockey
Nov 5, 2014·Patient Preference and Adherence·Anne-Marie Egert-SchmidtSusanne Thum-Oltmer
Apr 13, 2015·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Carlo Lombardi
Jul 22, 2015·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Ravi VaswaniSurender Vaswani
Jan 1, 2016·International Forum of Allergy & Rhinology·Brittany A LeaderSarah K Wise
Feb 9, 2016·The Journal of Allergy and Clinical Immunology·Marek JutelCezmi A Akdis
Nov 8, 2016·Human Vaccines & Immunotherapeutics·Fardous MusaWaleed Al-Herz
Jan 25, 2017·Patient Preference and Adherence·Marie-Luise LembergRalph Mösges
Jul 27, 2018·International Forum of Allergy & Rhinology·Yongshi YangRongfei Zhu
Aug 4, 2018·Journal of Investigational Allergology & Clinical Immunology·C CarusoA Romano
Oct 12, 2018·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Jordan TeachoutKaryn Gell
Dec 12, 2018·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Tugba S Tat

❮ Previous
Next ❯

Citations

Mar 24, 2021·The Journal of Allergy and Clinical Immunology. in Practice·Erika Jensen-JarolimIsabella Pali-Schöll
Jun 15, 2021·The World Allergy Organization Journal·Ilkay Koca KalkanSenay Demir
Jun 16, 2021·Current Opinion in Allergy and Clinical Immunology·Giovanni Passalacqua, Diego Bagnasco

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.