Adherence to antiretroviral therapy in a clinical cohort of HIV-infected children in East Africa

PloS One
Rachel C VreemanSarah E Wiehe

Abstract

To describe antiretroviral therapy (ART) adherence and associated factors for a large HIV-infected pediatric cohort followed by sites of the East Africa International Epidemiologic Databases to Evaluate AIDS (IeDEA) consortium. This study utilized prospectively collected clinical data from HIV-infected children less than 13 years of age who initiated ART within 4 clinical care programs (with 26 clinical sites) in Kenya, Uganda, and Tanzania and were followed for up to 6 years. Programs used one of 3 adherence measures, including 7-day quantitative recall, 7-day categorical recall, and clinician pill assessments. We fit a hierarchical, three-level, logistic-regression model to examine adherence, with observations nested within patient, and patients within the 26 sites providing pediatric HIV data to this analysis. In East Africa, 3,304 children, 52.0% male, were enrolled in care and were subsequently observed for a median of 92 weeks (inter-quartile range [IQR] 50.3-145.0 weeks). Median age at ART initiation was 5.5 years ([IQR] 3.0-8.5 years). "Good" adherence, as reported by each clinic's measures, was extremely high, remaining on average above 90% throughout all years of follow-up. Longer time on ART was associated with highe...Continue Reading

References

Jun 6, 2002·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Patricia García de OlallaJoan A Caylà
Nov 1, 2003·BMJ : British Medical Journal·D M GibbUNKNOWN National Study of HIV in Pregnancy and Childhood Collaborative HIV Paediatric Study

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R Foundation for Statistical Computing
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