Abstract
In 1998, with the launch of the Senegalese Initiative for Antiretroviral Access (ISAARV), Senegal became one of the first African countries to propose an antiretroviral access program. Our objective in this paper is to study the time to any first drug resistance, as well as predictors of the time to resistance. We propose a joint model to study the effect of adherence to the HAART therapy, and virological response on the time to resistance mutations. A logistic mixed model is used to model the time-dependent adherence process; and a Markov model is used to study the virological response. Given the presence of missing data in the adherence process and in the virological response, the latent adherence and virological states are then included in the linear predictor of the time to resistance model. The proposed time to resistance model takes into account interval-censored data as well as null hazard periods, during which the viral replication is very low. A Bayesian approach is used for accommodating with missing data and for prediction. We also propose model checking tools to study model adequacy.
References
Jul 6, 2000·Annals of Internal Medicine·D L PatersonN Singh
Apr 25, 2001·The Journal of Infectious Diseases·W HuangJ Mellors
Jul 20, 2002·AIDS·Christian LaurentEric Delaporte
Jun 12, 2003·AIDS·Catherine OrrellRobin Wood
Apr 15, 2004·Clinical Pharmacokinetics·Jennifer R KingEdward P Acosta
Aug 17, 2004·Epidemiology·Miguel A HernánJames M Robins
Sep 8, 2004·Trends in Cognitive Sciences·Susan A Gelman
Feb 22, 2005·The Journal of Antimicrobial Chemotherapy·Gregory M Lucas
Jun 14, 2005·International Journal of STD & AIDS·M RubioJ P Pometan
May 3, 2006·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Maria Patrizia CarrieriBruno Spire
May 13, 2006·AIDS·Jean-François EtardEric Delaporte
Jun 7, 2006·Statistics in Medicine·M Tournoud, R Ecochard
Aug 15, 2006·JAMA : the Journal of the American Medical Association·Scott M HammerUNKNOWN International AIDS Society-USA panel
Sep 23, 2006·The Journal of Infectious Diseases·Robert GrossRobert S Hogg
Apr 24, 2007·Biometrics·Chengcheng Hu, Victor De Gruttola
Oct 25, 2007·Tropical Medicine & International Health : TM & IH·Jean-François EtardUNKNOWN ANRS 1215/1290 Study Group
Citations
Dec 18, 2012·Journal of Clinical Microbiology·Moussa ThiamCoumba Toure-Kane
Jun 24, 2010·AIDS Research and Therapy·Reshmie Ramautarsing, Jintanat Ananworanich
Mar 3, 2011·PloS One·Sebastiaan M BolAngélique B van 't Wout