Adherence to cardiovascular medication: a review of systematic reviews

Journal of Public Health
K H LeslieJ P Pell

Abstract

Use of cardiovascular medication has increased over time, especially for primary and secondary prevention, with polypharmacy common. Review of published systematic reviews of the factors and outcomes associated with adherence to cardiovascular medication using MEDLINE, Embase, CINAHL and PsycINFO databases. Quality was assessed using the AMSTAR tool. Of 789 systematic reviews identified, 45 met the inclusion criteria and passed the quality assessment; 34 focused on factors associated with adherence, and 11 on outcomes. High heterogeneity, both between and within reviews, precluded meta-analysis and so a pooled estimate of adherence levels could not be derived. Adherence was associated with disease factors, therapy factors, healthcare factors, patient factors and social factors, though with some inconsistencies. In total, 91% of reviews addressing outcomes reported that low adherence was associated with poorer clinical and economic endpoints. Factors from across five key domains relate to non-adherence to cardiovascular medications, and may contribute to poorer clinical outcomes. Interventions to improve adherence should be developed to address modifiable factors and targeted at those at highest risk of non-adherence. Adherence ...Continue Reading

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Citations

May 16, 2020·International Journal of Environmental Research and Public Health·Carles Vilaplana-CarnereroMaria Rubio-Valera
Sep 6, 2020·Archives of Osteoporosis·Madeline S Wilton-ClarkEmma O Billington
Feb 12, 2021·Pharmacology Research & Perspectives·David ThompsonUNKNOWN ORBITA Investigators
Feb 2, 2021·Hellenic Journal of Cardiology : HJC = Hellēnikē Kardiologikē Epitheōrēsē·John YfantopoulosKonstantinos Tsioufis
Feb 20, 2021·International Journal of Cardiology·Ana Barradas-PiresKonstantinos Dimopoulos
Apr 27, 2021·Acta Cardiologica·Leonardo Di GennaroRaimondo De Cristofaro
Aug 17, 2021·Blood Pressure·Michel BurnierUNKNOWN Working Group on Cardiovascular Therapy and Adherence of the European Society of Hypertension

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Software Mentioned

AMSTAR
EndNote

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