Adherence to Guidelines for Adjuvant Imatinib Therapy for GIST: A Multi-institutional Analysis.

Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract
Danielle A BischofTimothy M Pawlik

Abstract

Gastrointestinal stromal tumors (GIST) are the most common mesenchymal tumors of the gastrointestinal tract. Adjuvant imatinib therapy improves recurrence-free and overall survival following surgery for patients with high-risk GIST; however, the factors associated with use of adjuvant imatinib therapy are unclear, and adherence to adjuvant imatinib has not been investigated. We sought to determine the clinicopathologic predictors of therapy with adjuvant imatinib following surgical resection for GIST and to determine the utilization of adjuvant imatinib in patients who underwent surgical resection of primary GIST in 2009 or later as recommended by National Comprehensive Cancer network (NCCN) guidelines. A multi-institutional cohort including 171 patients who underwent surgery for primary GIST at seven high-volume cancer centers in the USA and Canada between January 2009-December 2012 was used in this study. Receipt of adjuvant imatinib therapy was ascertained, and factors associated with imatinib therapy were analyzed. Following surgery for primary GIST, tumor size (<5.0 cm: ref; 5.0-9.9 cm: odds ratio (OR) 2.36, 95 % confidence interval (CI) 0.74-7.55; >10.0 cm: OR 9.15, 95 % CI 2.28-36.75; p = 0.007), mitotic rate (≤5/50 mito...Continue Reading

References

Aug 16, 2002·The New England Journal of Medicine·George D DemetriHeikki Joensuu
May 19, 2005·International Journal of Cancer. Journal International Du Cancer·Geir TryggvasonJón G Jónasson
May 3, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Michael C HeinrichUNKNOWN Imatinib Target Exploration Consortium Study B2225
Mar 24, 2009·Lancet·Ronald P DematteoUNKNOWN American College of Surgeons Oncology Group (ACOSOG) Intergroup Adjuvant GIST Study Team
Jul 22, 2009·Archives of Surgery·Charles E WoodallRobert C G Martin
Aug 24, 2010·The British Journal of Surgery·P HohenbergerP Reichardt
Nov 18, 2011·Nature Reviews. Cancer·Christopher L CorlessMichael C Heinrich
Mar 29, 2012·JAMA : the Journal of the American Medical Association·Heikki JoensuuPeter Reichardt
Oct 31, 2013·Annals of Surgery·Ryan P MerkowKarl Y Bilimoria

❮ Previous
Next ❯

Citations

Jun 24, 2016·Journal of Surgical Oncology·Ravinder KangSandra L Wong
Feb 6, 2017·Cirugía española·Ana María Carrillo ColmeneroPedro López Leiva
May 2, 2019·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Toshirou NishidaUNKNOWN members of the STAR ReGISTry Study Group
Apr 20, 2021·Journal of Gastrointestinal Cancer·S Lopez GordoL Farran
May 29, 2021·Annals of Surgical Oncology·Rachel K VossChristina L Roland

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
Jian LiLin Shen
Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract
Danielle A BischofTimothy M Pawlik
Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract
Gerd R SilberhumerJohannes Zacherl
© 2022 Meta ULC. All rights reserved