Adherence to osteoporosis therapy after an upper extremity fracture: a pre-specified substudy of the C-STOP randomized controlled trial

Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA
Finlay A McAlisterSumit R Majumdar

Abstract

Despite their proven efficacy for secondary fracture prevention, long-term adherence with oral bisphosphonates is poor. To compare the effectiveness of two interventions on long-term oral bisphosphonate adherence after an upper extremity fragility fracture. Community-dwelling participants 50 years or older with upper extremity fragility fractures not previously treated with bisphosphonates were randomized to either a multi-faceted patient and physician educational intervention (the active control arm) vs. a nurse-led case manager (the study arm). Primary outcome was adherence (taking > 80% of prescribed doses) with prescribed oral bisphosphonates at 12 months postfracture between groups; secondary outcomes included rates of primary non-adherence and 24-month adherence. We also compared quality of life between adherent and non-adherent patients. By 12 months, adherence with the initially prescribed bisphosphonate was similar (p = 0.96) in both groups: 38/48 (79.2%) in the educational intervention group vs. 66/83 (79.5%) in the case manager arm. By 24 months, adherence rates were 67% (32/48) in the educational intervention group vs. 53% (43/81) in case managed patients (p = 0.13). Primary non-adherence was 6% (11 patients) in the...Continue Reading

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References

Mar 1, 1997·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·E LydickR Holmes
Jun 6, 2003·Journal of Evaluation in Clinical Practice·Allen W HeinemannJennifer Clumpner
Jul 20, 2004·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·V Elliot-GibsonD E Beaton
May 24, 2005·Medical Care·Michael C SokolRobert S Epstein
Dec 6, 2006·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Russel BurgeAnna Tosteson
Feb 20, 2007·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·J A CramerE M Lewiecki
Jun 21, 2008·Medical Decision Making : an International Journal of the Society for Medical Decision Making·François-Emery CottéGérard De Pouvourville
Oct 18, 2008·Bone·Adrianne C FeldsteinNancy Perrin
Feb 5, 2009·JAMA : the Journal of the American Medical Association·Dana BliucJacqueline R Center
Apr 3, 2009·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Lisa LangsetmoUNKNOWN CaMos Research Group
Apr 19, 2013·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·K ReynoldsC D O'Malley
May 28, 2013·International Archives of Medicine·Helena Parente VieiraFernando Adami
Jul 31, 2013·Frontiers in Pharmacology·Przemyslaw KardasMichal Matyjaszczyk
Jan 22, 2014·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·K GandaM J Seibel
Mar 19, 2014·JAMA Internal Medicine·Peter S HusseyCraig Evan Pollack
Mar 31, 2015·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·C KlopF de Vries
Jul 18, 2016·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·L A WozniakS R Majumdar
Aug 20, 2016·Journal of the American College of Cardiology·Paul W Armstrong, Finlay A McAlister
Jul 25, 2018·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Sumit R MajumdarLauren A Beaupre

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Citations

Feb 20, 2019·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Sumit R MajumdarLauren A Beaupre
Dec 12, 2019·Lupus·J NordqvistH Carlsten
Nov 18, 2019·Current Osteoporosis Reports·Paul J MitchellM Kassim Javaid
Nov 13, 2019·The Journal of Bone and Joint Surgery. American Volume·Andréa SenayJulio C Fernandes
Apr 9, 2020·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·M K JavaidC Cooper
Sep 6, 2020·Archives of Osteoporosis·Madeline S Wilton-ClarkEmma O Billington
Apr 18, 2021·Archives of Osteoporosis·Mary E WalshFrank Moriarty

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