Adherence to routine use of pharmacological prophylaxis of heterotopic ossification after total hip arthroplasty: results from an Italian multicenter, prospective, observational survey.

Journal of Orthopaedics and Traumatology : Official Journal of the Italian Society of Orthopaedics and Traumatology
Michele BarbatoCarlo Luca Romanò

Abstract

In spite of the proven efficacy of pharmacological prophylaxis of heterotopic ossification following total hip arthroplasty, its routine use is still debated, and no data are available regarding the adherence to its administration in clinical practice. In this prospective, observational, multicenter study, 480 consecutive patients operated on for primary total hip arthroplasty during the year 2009 were followed radiographically for 12 months after surgery in order to assess the incidence of periprosthetic heterotopic ossification. Surgeons were free to choose whether to administer pharmacological prophylaxis, and were asked to keep a record of the duration of the prophylaxis (if used) or the reasons for not using it. To facilitate the statistical analysis, all of the participating centers agreed to use only one drug (celecoxib) that had already proven to be effective. 368 patients were administered celecoxib and 112 patients did not receive any prophylaxis. Reported reasons for not administering celecoxib prophylaxis were the surgeon's opinion that prophylaxis was not needed on a routine basis (84/112 patients, 75%), previous history of gastrointestinal bleeding (17.8%), and concomitant cardiorenal pathologies (7.1%). The overa...Continue Reading

References

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Citations

Apr 17, 2014·The Journal of Arthroplasty·Hassan AloshGwo-Chin Lee
Sep 26, 2019·Radiology and Oncology·Bilal MujtabaRizwan Aslam
Jul 3, 2015·The Journal of Bone and Joint Surgery. American Volume·Kavitha RanganathanBenjamin Levi
Jun 16, 2015·Clinical and Translational Science·Jessica C RiveraChristopher R Rathbone
Aug 21, 2020·BMJ Case Reports·Chantal J NieuwenhuizenRobert F van Oosterom

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Methods Mentioned

BETA
total hip arthroplasty

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