Adherence to the Mediterranean diet attenuates inflammation and coagulation process in healthy adults: The ATTICA Study

Journal of the American College of Cardiology
Christina ChrysohoouChristodoulos Stefanadis

Abstract

We studied the effect of the Mediterranean diet on plasma levels of C-reactive protein (CRP), white blood cell counts, interleukin (IL)-6, tumor necrosis factor (TNF)-alpha, amyloid A, fibrinogen, and homocysteine. To the best of our knowledge, the mechanism(s) by which the Mediterranean diet reduces cardiovascular risk are not well understood. During the 2001 to 2002 period, we randomly enrolled 1,514 men (18 to 87 years old) and 1,528 women (18 to 89 years old) from the Attica area of Greece (of these, 5% of men and 3% of women were excluded because of a history of cardiovascular disease). Among several factors, adherence to the Mediterranean diet was assessed by a diet score that incorporated the inherent characteristics of this diet. Higher values of the score meant closer adherence to the Mediterranean diet. Participants who were in the highest tertile of the diet score had, on average, 20% lower CRP levels (p = 0.015), 17% lower IL-6 levels (p = 0.025), 15% lower homocysteine levels (p = 0.031), 14% lower white blood cell counts (p = 0.001), and 6% lower fibrinogen levels (p = 0.025), as compared with those in the lowest tertile. The findings remained significant even after various adjustments were made. Borderline associ...Continue Reading

References

Mar 25, 2000·Journal of the American College of Cardiology·J J PiekA E Becker
Apr 3, 2001·Circulation·P Libby, D I Simon
Dec 20, 2002·Nature·Peter Libby
Jun 27, 2003·The New England Journal of Medicine·Antonia TrichopoulouDimitrios Trichopoulos

❮ Previous
Next ❯

Citations

Oct 13, 2006·Archives of Neurology·Nikolaos ScarmeasJose A Luchsinger
Feb 11, 2009·Archives of Neurology·Nikolaos ScarmeasJose A Luchsinger
Nov 20, 2012·Social Psychiatry and Psychiatric Epidemiology·Felice N JackaStephen A Stansfeld
Dec 6, 2008·The European Journal of Health Economics : HEPAC : Health Economics in Prevention and Care·Andreas C DrichoutisRodolfo M Nayga
Oct 22, 2008·Current Atherosclerosis Reports·Francesco VisioliRodolfo Paoletti
Jun 19, 2010·Journal of Cardiovascular Translational Research·Delfin Rodriguez-LeyvaGrant N Pierce
Mar 6, 2009·The Journal of Nutrition, Health & Aging·N AlipanahR D Semba
Nov 21, 2007·The British Journal of Nutrition·Julia WärnbergAscensión Marcos
Aug 13, 2009·The British Journal of Nutrition·Ruth ChanNelson Tang
Jan 11, 2013·The British Journal of Nutrition·Chantal JuliaEmmanuelle Kesse-Guyot
Dec 17, 2009·The Proceedings of the Nutrition Society·Pascal P McKeownJayne V Woodside
Jun 3, 2010·The Proceedings of the Nutrition Society·Ramon Estruch
Oct 8, 2008·Public Health Nutrition·Dora RomagueraAntonia Trichopoulou
Aug 20, 2009·Public Health Nutrition·Nancy BabioJordi Salas-Salvadó
Apr 1, 2010·Public Health Nutrition·Alexia KatsarouDemosthenes Panagiotakos
Oct 24, 2013·European Journal of Clinical Nutrition·M Del Mar BibiloniJ A Tur
Feb 1, 2012·Molecular Psychiatry·C L Raison, A H Miller
Apr 19, 2007·European Journal of Clinical Nutrition·J Salas-SalvadóUNKNOWN PREDIMED Investigators
Jan 6, 2006·International Journal of Impotence Research·K EspositoD Giugliano
Oct 4, 2012·Translational Psychiatry·S GardenerUNKNOWN AIBL Research Group
Jan 10, 2010·Food & Function·Khedidja MekkiMalika Bouchenak
Sep 6, 2008·Proceedings of the National Academy of Sciences of the United States of America·S TerésP V Escribá
Aug 23, 2006·The British Journal of Nutrition·Pagona LagiouHans-Olov Adami
Mar 4, 2006·Public Health Nutrition·Michel de Lorgeril, Patricia Salen
Oct 7, 2010·Nutrition and Cancer·Lisa VerberneLluis Serra-Majem
Mar 22, 2013·Journal of Medicinal Food·Konstantinos KatsiardanisEleni T Petridou
Mar 29, 2008·Metabolic Syndrome and Related Disorders·Katherine EspositoDario Giugliano
Mar 5, 2013·Metabolic Syndrome and Related Disorders·Giovanni ViscogliosiPaola Andreozzi
Jul 3, 2008·Rejuvenation Research·Fulvio LauretaniLuigi Ferrucci
Nov 26, 2008·European Heart Journal·Charalambos AntoniadesChristodoulos Stefanadis
Feb 27, 2009·International Journal of Epidemiology·Demosthenes B PanagiotakosUNKNOWN AIRGENE Study Group
Mar 16, 2005·Current Opinion in Lipidology·Robert Cramb
Apr 9, 2005·Southern Medical Journal·David P Rakel, Adam Rindfleisch
Jan 16, 2007·Current Opinion in Lipidology·Valerie H Myers, Catherine M Champagne
May 25, 2011·Alzheimer Disease and Associated Disorders·Yian GuNikolaos Scarmeas
May 8, 2008·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Shauna M Downs, Noreen D Willows
Nov 29, 2007·Neuroepidemiology·Nikolaos Scarmeas, Elan D Louis

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiovascular Diseases: Risk Factors

Cardiovascular disease is a significant health concern. Risk factors include hypertension, obesity, dyslipidemia and smoking. Women who are postmenopausal are at an increased risk of heart disease. Here is the latest research for risk factors of cardiovascular disease.

Cardiovascular Inflammation

Inflammation plays a significant role in the development of cardiovascular diseases, an understanding of these endogenous processes is critical for evaluating the risks and potential treatment strategies. Discover the latest research on cardiovascular inflammation here.

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

Cardiology Journals

Discover the latest cardiology research in this collection of the top cardiology journals.

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.