Adherence to World Glaucoma Association Guidelines for Surgical Trials in the Era of Microinvasive Glaucoma Surgeries.

Ophthalmology. Glaucoma
David J MathewYvonne M Buys

Abstract

To determine how well microinvasive glaucoma surgical (MIGS) trials conform to the World Glaucoma Association (WGA) guidelines. Lack of well-designed MIGS studies hinders meaningful evaluation of these technologies. Cross-sectional literature survey. Using a predefined search strategy, the following databases were searched for comparative trials involving MIGS in the English peer-reviewed literature from January 1, 2000, through June 21, 2018: Medline, EMBASE, BIOSIS, Cochrane, and Web of Science. From the WGA guidelines, 53 outcomes were selected for evaluation: methodology (n = 31), definition of success (n = 7), ethics (n = 10), postoperative complications (n = 1), economic evaluation (n = 1), and statistical reporting (n = 3). Each article was assessed by 2 reviewers; differences were resolved by consensus. Twenty-five eligible publications were identified: 10 randomized controlled trials (RCTs) and 15 nonrandomized comparative trials (non-RCTs). The mean follow-up was 19.9±11.6 months (range, 6-48 months). The mean number of outcomes adhering to the WGA guidelines of the 53 evaluated was 24.2±6.1 (45.6% compliance): 28.0±6.2 (52.8%) and 21.6±4.7 (40.8%) for RCTs and non-RCTs, respectively (P = 0.01). Mean percent complianc...Continue Reading

Citations

Sep 17, 2020·Annual Review of Vision Science·David J Mathew, Yvonne M Buys
Oct 30, 2020·Clinical Ophthalmology·Domenico GrossoGiuseppe Querques
Jun 21, 2020·Progress in Retinal and Eye Research·Gordana Sunaric Megevand, Alain M Bron
Apr 20, 2021·Journal of Current Glaucoma Practice·Tanuj DadaShibal Bhartiya
Oct 1, 2020·Survey of Ophthalmology·Prem NichaniIqbal Ike K Ahmed
Jun 8, 2021·Ophthalmology. Glaucoma·Matt Schlenker, Vinay Kansal

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