Abstract
Using electron microscopy, we prospectively evaluated how frequently adherent microorganisms colonized silicone rubber intravenous (Hickman) catheters removed from patients with cancer. Thirteen (87%) of 15 catheters had gram-positive cocci in glycocalyx adherent to the surface of the catheter lumen. Fungal elements or gram-negative bacilli were mixed with the gram-positive cocci in the glycocalyx on the lumens of three catheters. A consistent morphologic form was adherent to, and the same species was recovered from, the corresponding catheter for six of 27 organisms causing septicemia during catheterization: four of five Staphylococcus epidermidis bacteremias and the only Staphylococcus aureus bacteremia, and one of five candidemias. Three of these six septicemias were successfully treated without removal of the catheter. Although adherent organisms, particularly S epidermidis, were likely to be present on the surface of the lumen of long-term, indwelling, silicone intravenous catheters, septicemias potentially related to these organisms occurred infrequently (fewer than two per 1000 days of catheter use), and the suspect septicemias could sometimes be treated without removal of the catheter.
Citations
Mar 1, 1994·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·S C SchimpffJ C Wade
May 1, 1991·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·D SticklerJ Chawla
Feb 1, 1995·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·E AnaissieI Raad
Sep 1, 1994·Clinical Rheumatology·F AglasG J Krejs
Nov 28, 2001·Current Infectious Disease Reports·Michael Bell
Apr 1, 1995·The American Journal of Medicine·D K RileyJ P Burke
Jun 1, 1994·Epidemiology and Infection·S P GormanW M Mawhinney
May 10, 2012·Langmuir : the ACS Journal of Surfaces and Colloids·Christoph BarthPatrick Koelsch
Jan 1, 1995·Eye·M J ElderJ K Dart
Sep 21, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·R M Donlan
Aug 1, 1993·Annals of Surgery·J S GroegerP Exelby
Nov 1, 1988·Antimicrobial Agents and Chemotherapy·J L RootC P Daghlian
Nov 1, 1989·Antimicrobial Agents and Chemotherapy·P Yagupsky, M A Menegus
Sep 1, 1993·Antimicrobial Agents and Chemotherapy·H YasudaT Yokota
Feb 19, 2002·Antimicrobial Agents and Chemotherapy·Zhilan Zheng, Philip S Stewart
Apr 5, 2002·Clinical Microbiology Reviews·Rodney M Donlan, J William Costerton
Mar 11, 1998·Journal of Hand Therapy : Official Journal of the American Society of Hand Therapists·C Lau
Jun 16, 2000·Journal of Hand Therapy : Official Journal of the American Society of Hand Therapists·J A McAuliffe, R E Miller
Aug 14, 2010·La Revue de médecine interne·D LebeauxB Fantin
Jun 1, 1996·American Journal of Infection Control·G R JonesR P Dunaway
May 23, 2015·Molecular Pharmaceutics·Yaswanth KuthatiChia-Hung Lee
Jan 11, 2005·Hematology/oncology Clinics of North America·Rachel P Rosovsky, David J Kuter