Adhesins of Brucella : Their Roles in the Interaction with the Host

Pathogens
Magalí G BialerAngeles Zorreguieta

Abstract

A central aspect of Brucella pathogenicity is its ability to invade, survive, and replicate in diverse phagocytic and non-phagocytic cell types, leading to chronic infections and chronic inflammatory phenomena. Adhesion to the target cell is a critical first step in the invasion process. Several Brucella adhesins have been shown to mediate adhesion to cells, extracellular matrix components (ECM), or both. These include the sialic acid-binding proteins SP29 and SP41 (binding to erythrocytes and epithelial cells, respectively), the BigA and BigB proteins that contain an Ig-like domain (binding to cell adhesion molecules in epithelial cells), the monomeric autotransporters BmaA, BmaB, and BmaC (binding to ECM components, epithelial cells, osteoblasts, synoviocytes, and trophoblasts), the trimeric autotransporters BtaE and BtaF (binding to ECM components and epithelial cells) and Bp26 (binding to ECM components). An in vivo role has also been shown for the trimeric autotransporters, as deletion mutants display decreased colonization after oral and/or respiratory infection in mice, and it has also been suggested for BigA and BigB. Several adhesins have shown unipolar localization, suggesting that Brucella would express an adhesive p...Continue Reading

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Citations

May 15, 2021·Frontiers in Cellular and Infection Microbiology·Magalí G BialerAngeles Zorreguieta
Aug 10, 2021·Annals of Medicine and Surgery·Fatehi ElzeinAhmed Al Fagih

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Methods Mentioned

BETA
scanning electron microscopy
electron microscopy
ELISA
phage display
footprinting
electrophoretic mobility shift assay

Software Mentioned

TA Domain Annotation ( daTAA )

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