Adhesion and aggregation of thrombin prestimulated human platelets: evaluation of surface-bound fibrinogen and surface-bound albumin

Thrombosis Research
I A Feuerstein, L E Skupny-Garnham

Abstract

The effect of prestimulation of human washed platelets with thrombin on their ability to adhere to and form aggregates on fibrinogen- and albumin-coated glass has been studied. Prestimulation of platelets does not alter platelet adhesion to surface bound albumin and fibrinogen. Our data for both protein coatings support a mechanism of adherence of single prestimulated platelets before formation of surface-bound aggregates from single platelets arriving from the flow. When whole blood contacts an artificial surface, thrombin will likely influence the platelet component of thrombus formation.

References

Jan 1, 1979·Annual Review of Medicine·H Holmsen, H J Weiss
Feb 1, 1986·Journal of Biomechanical Engineering·I A Feuerstein, J Kush
Feb 1, 1972·British Journal of Haematology·J F MustardM A Packham
Apr 1, 1974·Canadian Journal of Physiology and Pharmacology·T M Chang
Dec 15, 1982·Thrombosis Research·G J TangelderR S Reneman

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Citations

Jan 1, 1987·Annals of the New York Academy of Sciences·I A Feuerstein

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