Adhesion failures determine the pattern of choroidal neovascularization in the eye: a computer simulation study.

PLoS Computational Biology
Abbas ShirinifardHans E Grossniklaus

Abstract

Choroidal neovascularization (CNV) of the macular area of the retina is the major cause of severe vision loss in adults. In CNV, after choriocapillaries initially penetrate Bruch's membrane (BrM), invading vessels may regress or expand (CNV initiation). Next, during Early and Late CNV, the expanding vasculature usually spreads in one of three distinct patterns: in a layer between BrM and the retinal pigment epithelium (sub-RPE or Type 1 CNV), in a layer between the RPE and the photoreceptors (sub-retinal or Type 2 CNV) or in both loci simultaneously (combined pattern or Type 3 CNV). While most studies hypothesize that CNV primarily results from growth-factor effects or holes in BrM, our three-dimensional simulations of multi-cell model of the normal and pathological maculae recapitulate the three growth patterns, under the hypothesis that CNV results from combinations of impairment of: 1) RPE-RPE epithelial junctional adhesion, 2) Adhesion of the RPE basement membrane complex to BrM (RPE-BrM adhesion), and 3) Adhesion of the RPE to the photoreceptor outer segments (RPE-POS adhesion). Our key findings are that when an endothelial tip cell penetrates BrM: 1) RPE with normal epithelial junctions, basal attachment to BrM and apical...Continue Reading

References

Sep 1, 1977·The British Journal of Ophthalmology·N F Johnson, W S Foulds
Jan 1, 1983·Transactions of the New Orleans Academy of Ophthalmology·S J Ryan
Dec 1, 1995·Archives of Ophthalmology·L P AielloM A Iwamoto
Jan 1, 1994·Eye·J P SarksM C Killingsworth
Jan 1, 1996·Retina·M G Maguire, S L Fine
Oct 1, 1996·Cardiovascular Research·A R PriesP Gaehtgens
Feb 1, 1997·The British Journal of Ophthalmology·M KliffenP T de Jong
Mar 1, 1993·Physical Review. E, Statistical Physics, Plasmas, Fluids, and Related Interdisciplinary Topics·J A Glazier, F Graner
Oct 28, 1999·Current Opinion in Ophthalmology·R F Spaide
Dec 14, 1999·Survey of Ophthalmology·J I Lim
Aug 8, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·S K ShawF W Luscinskas
Apr 13, 2002·Experimental Eye Research·Kazushi TamaiDonald Armstrong
Apr 19, 2003·The EMBO Journal·Guido SeriniFederico Bussolino
Jan 15, 2004·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Gottfried MartinHansjürgen T Agostini
Mar 12, 2004·American Journal of Ophthalmology·Hans E Grossniklaus, W Richard Green
Apr 14, 2004·Archives of Ophthalmology·Marco A Zarbin
Aug 25, 2004·Investigative Ophthalmology & Visual Science·Tongalp H TezelHenry J Kaplan
Jan 27, 2005·Experimental Eye Research·Vamsi K GullapalliMarco A Zarbin
Feb 12, 2005·American Journal of Physiology. Heart and Circulatory Physiology·A R Pries, T W Secomb
Feb 17, 2005·Physiological Measurement·Magnus W Roos
Feb 22, 2005·Journal of Theoretical Biology·Dominik Szczerba, Gábor Székely
Dec 6, 2005·Developmental Biology·Roeland M H MerksJames A Glazier
Dec 16, 2005·Nature·Peter Carmeliet

❮ Previous
Next ❯

Citations

Jun 1, 2014·Optometry and Vision Science : Official Publication of the American Academy of Optometry·Lisa Nivison-SmithMichael Kalloniatis
Apr 12, 2016·Progress in Retinal and Eye Research·Paul A RobertsHelen M Byrne
Sep 11, 2012·Current Opinion in Genetics & Development·Pawel KrupinskiCarsten Peterson
Apr 27, 2017·Journal of Lipid Research·Seyedeh Maryam ZekavatNorman A Mazer
Dec 24, 2013·New Journal of Physics·András CzirókAndrás Szabó
Sep 17, 2016·PloS One·James P SlukaJames A Glazier
Jun 15, 2016·PLoS Computational Biology·Xiao FuThomas J Gast
Feb 16, 2013·European Journal of Ophthalmology·Alon HarrisBrent A Siesky
Dec 2, 2020·Investigative Ophthalmology & Visual Science·Fabiola BiasellaUlrike Friedrich
Nov 20, 2020·Physical Biology·Nicola Mulberry, Leah Edelstein-Keshet
Mar 7, 2021·Biomedicines·Rocío VegaLuis L Bonilla
May 3, 2021·Journal of Cellular and Molecular Medicine·Joe M ButlerLuminita Paraoan
Jun 11, 2021·Translational Vision Science & Technology·Cheikh DiackNicolas Frey

❮ Previous
Next ❯

Software Mentioned

CompuCell3D

Related Concepts

Related Feeds

Arterial-Venous in Development & Disease

Arterial-venous development may play a crucial role in cardiovascular diseases. Here is the latest research.

Basement Membranes

Basement membranes are thin, specialized extracellular matrices surrounding most tissues in all metazoans. Here is the latest research on basement membranes.

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.

Related Papers

Current Opinion in Cell Biology
Vanessa Barone, Carl-Philipp Heisenberg
PLoS Computational Biology
Kevin K ChiouBoris I Shraiman
© 2021 Meta ULC. All rights reserved