Adhesion GPCRs in Kidney Development and Disease

Frontiers in Cell and Developmental Biology
Salvador Cazorla-Vázquez, Felix B Engel

Abstract

Chronic kidney disease (CKD) represents the fastest growing pathology worldwide with a prevalence of >10% in many countries. In addition, kidney cancer represents 5% of all new diagnosed cancers. As currently no effective therapies exist to restore kidney function after CKD- as well as cancer-induced renal damage, it is important to elucidate new regulators of kidney development and disease as new therapeutic targets. G protein-coupled receptors (GPCRs) represent the most successful class of pharmaceutical targets. In recent years adhesion GPCRs (aGPCRs), the second largest GPCR family, gained significant attention as they are present on almost all mammalian cells, are associated to a plethora of diseases and regulate important cellular processes. aGPCRs regulate for example cell polarity, mitotic spindle orientation, cell migration, and cell aggregation; all processes that play important roles in kidney development and/or disease. Moreover, polycystin-1, a major regulator of kidney development and disease, contains a GAIN domain, which is otherwise only found in aGPCRs. In this review, we assess the potential of aGPCRs as therapeutic targets for kidney disease. For this purpose we have summarized the available literature and a...Continue Reading

References

Jan 1, 1986·Anatomy and Embryology·L SaxénE Lehtonen
Sep 1, 1996·The Journal of Experimental Medicine·J HamannR A van Lier
May 14, 1999·Developmental Genetics·J A Davies
Apr 1, 2000·International Immunology·J HamannR A van Lier
Sep 23, 2000·Nature·P Carmeliet, R K Jain
Jul 14, 2001·Tissue Antigens·L H JasparsJ Hamann
Dec 26, 2001·Current Opinion in Nephrology and Hypertension·Hannu Sariola
Jan 24, 2002·AJR. American Journal of Roentgenology·Brian R HertsMark E Baker
Nov 5, 2002·The American Journal of Pathology·Matthias SteinertGabriela Aust
Jun 20, 2003·Veterinary Immunology and Immunopathology·José M Pérez de la LastraDiego Llanes
Dec 6, 2003·Molecular Biology of the Cell·John P T HigginsMatt van de Rijn
Jun 16, 2004·Developmental Biology·Tomoko Watanabe, Frank Costantini
Jan 25, 2005·Lancet·A Meguid El Nahas, Aminu K Bello
Mar 18, 2005·Annual Review of Immunology·P R TaylorS Gordon
Mar 31, 2005·American Journal of Physiology. Renal Physiology·Maribel RicoJohn R Sedor
May 27, 2005·Journal of the American Society of Nephrology : JASN·Kai M Schmidt-OttJonathan Barasch
Nov 23, 2005·Oncology·Peter Carmeliet
Jan 6, 2006·Journal of the American Society of Nephrology : JASN·Elena Galkina, Klaus Ley
Feb 2, 2006·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Jackelyn A AlvaM Luisa Iruela-Arispe
Aug 8, 2006·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Sunfa ChengDavid H Lovett
Oct 4, 2006·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Sally E DoyleRaymond B Runyan
Oct 24, 2006·Gene·Thóra K BjarnadóttirHelgi B Schiöth
Nov 15, 2006·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Srinivasa R PrasadKedar N Chintapalli
Dec 28, 2006·American Journal of Physiology. Renal Physiology·J M CataniaA R Parrish
Apr 25, 2007·Gene Expression Patterns : GEP·Melissa H LittleJing Yu
Sep 8, 2007·European Journal of Immunology·Jörg HamannMark J Kwakkenbos
Oct 13, 2007·Molecular and Cellular Biochemistry·Yue HuangGuo-Zhang Zhu
Feb 8, 2008·Journal of the American Society of Nephrology : JASN·Juan F Navarro-González, Carmen Mora-Fernández
Apr 3, 2008·Nature Reviews. Drug Discovery·Malin C Lagerström, Helgi B Schiöth
Aug 22, 2008·Journal of the American Society of Nephrology : JASN·Gregory R Dressler
Oct 23, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Henrike VeningaJörg Hamann
Nov 13, 2008·Developmental Cell·Eric W BrunskillS Steven Potter
Apr 4, 2009·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·K P McCulloughA B Leichtman

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Citations

Jul 11, 2020·Expert Opinion on Drug Discovery·Andrey D BondarevHelgi B Schiöth
Aug 30, 2019·Nature Reviews. Drug Discovery·Frederic BassilanaMarie-Gabrielle Ludwig
May 13, 2019·Trends in Pharmacological Sciences·Paul A InselAmy M Chinn
Apr 27, 2020·Cellular Signalling·Caroline R SussmanVicente E Torres
Jun 24, 2021·Nature Reviews. Molecular Cell Biology·Terry Lechler, Marina Mapelli
May 25, 2021·American Journal of Physiology. Renal Physiology·Brian G PollMark A Knepper
Nov 4, 2021·The FEBS Journal·Ines LiebscherSimone Prömel

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Methods Mentioned

BETA
RNAseq
PCR
Nephroseq
xenograft

Software Mentioned

FireBrowse
Omics
EURExpress
Google Scholar
cBioPortal
Nephroseq

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