Adhesion-induced eosinophil cytolysis requires the receptor-interacting protein kinase 3 (RIPK3)-mixed lineage kinase-like (MLKL) signaling pathway, which is counterregulated by autophagy

The Journal of Allergy and Clinical Immunology
Susanne Radonjic-HoesliHans-Uwe Simon

Abstract

Eosinophils are a subset of granulocytes that can be involved in the pathogenesis of different diseases, including allergy. Their effector functions are closely linked to their cytotoxic granule proteins. Release takes place through several different mechanisms, one of which is cytolysis, which is associated with release of intact granules, so-called clusters of free eosinophil granules. The mechanism underlying this activation-induced form of cell death in eosinophils has remained unclear. We aimed to elucidate the molecular mechanism of eosinophil cytolysis. Isolated blood eosinophils were incubated on glass coverslips coated with intravenous immunoglobulin and inactive complement component 3b. A morphologic characterization of the distinct stages of the proposed cascade was addressed by means of time-lapse automated fluorescence microscopy, electron microscopy, and immunohistochemistry. Experiments with pharmacologic inhibitors were performed to elucidate the sequence of events within the cascade. Tissue samples of patients with eosinophilic skin diseases or eosinophilic esophagitis were used for in vivo analyses. After eosinophil adhesion, we observed reactive oxygen species production, early degranulation, and granule fusi...Continue Reading

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Citations

Jan 27, 2018·Cell Death & Disease·Xiaoliang WangHans-Uwe Simon
Sep 2, 2017·American Journal of Respiratory and Critical Care Medicine·Elizabeth A KellyNizar N Jarjour
Jan 11, 2019·European Journal of Immunology·Shida YousefiHans-Uwe Simon
Nov 30, 2018·Annual Review of Physiology·Maor SaulerPatty J Lee
Nov 22, 2019·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·Stephane EsnaultNizar N Jarjour
Jan 16, 2020·Biomolecules·Gur P KaushalSudhir V Shah
May 2, 2020·Cell Death & Disease·Shida YousefiHans-Uwe Simon
Apr 20, 2018·Journal of Leukocyte Biology·Paneez KhouryAmy D Klion
Nov 14, 2019·Cell Death & Disease·Tamás MolnárGábor Koncz
Aug 17, 2020·The Journal of Immunology : Official Journal of the American Association of Immunologists·Xiaoliang WangHans-Uwe Simon
Aug 1, 2020·Frontiers in Immunology·Jacob D PainterOmid Akbari
May 12, 2018·Journal of Leukocyte Biology·Rossana C N Melo, Peter F Weller
Feb 10, 2019·Cell Death and Differentiation·Nina GermicHans-Uwe Simon
Nov 22, 2019·Biochimica Et Biophysica Acta. Gene Regulatory Mechanisms·Karam Aboudehen
Dec 17, 2020·Biology·Martina ZustakovaPetr Slama
Feb 25, 2021·Scandinavian Journal of Immunology·Harald RenzJohannes Ring
May 22, 2021·Seminars in Immunopathology·Nina GermicHans-Uwe Simon
Jun 8, 2021·Seminars in Immunopathology·Susanne Radonjic-HoesliDagmar Simon
Jul 3, 2021·International Journal of Molecular Sciences·Efthymia Theofani, Georgina Xanthou
Jul 3, 2021·International Journal of Molecular Sciences·José M Rodrigo-MuñozVictoria Del Pozo
May 1, 2018·Journal of Proteome Research·Stephane EsnaultDeane F Mosher
Dec 2, 2019·International Archives of Allergy and Immunology·Hans-Uwe SimonHelene F Rosenberg

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