PMID: 9194580May 1, 1997Paper

Adhesion molecule expression in normal skin and melanocytic lesions. Role of UV-irradiation and architectural characteristics in nevi

Journal of Cutaneous Pathology
M TronnierH H Wolff

Abstract

Cell adhesion between surfaces of cells and to extracellular matrices represents a fundamental mechanism in tissue organization and influences the biological behaviour and the architecture of tumors. We investigated the expression of various adhesion molecules in normal skin (n=5), nevi (n=29), and malignant melanoma (n=10) by immunohistochemistry. Special attention was paid to the correlation between adhesion molecule expression and the respective architectural features, e.g. UV-induced morphological changes, and the arrangement of melanocytes in congenital nevi. In nevi, a single erythemagenic dose of UV-light did not influence the integrin expression of melanocytes, but results in an upregulation of alpha3 beta1- and alpha6 beta1-integrin within the suprabasal layers of the epidermis. This suprabasal labelling was associated with an increased number of suprabasal melanocytes in UV-irradiated nevi which were detected with HMB-45 antibody. Nine of 10 congenital nevi demonstrated a labelling of alpha4 beta1-integrin only in melanocytes of the deeper dermis. This integrin previously has been associated with high tumor thickness and the clinical outcome in melanomas. The integrin profile observed in melanomas differed in part fro...Continue Reading

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Citations

Jan 22, 2002·The American Journal of Dermatopathology·B Schubert, P Rudolph
Apr 7, 2007·The American Journal of Dermatopathology·Maria Angelica SelimJohn W Turner
Oct 20, 2007·Journal of Cutaneous Pathology·Dante Simionato NetoGilles Landman
Oct 24, 2008·The Journal of Investigative Dermatology·Michaela BrennerVincent J Hearing
Dec 29, 2016·Medicinal Research Reviews·Stanca A BirleaDavid A Norris
Dec 3, 1999·The British Journal of Dermatology·M NeitmannM Tronnier
May 12, 2005·Experimental Dermatology·Sven KrengelMichael Tronnier
Jan 22, 2003·The British Journal of Dermatology·Y GauthierA Taïeb
Aug 28, 2020·The American Journal of Dermatopathology·Wolfgang Weyers
Nov 16, 2005·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Michael Tronnier
Sep 17, 2004·Pathology·Vesna Petronic-RosicThomas Krausz

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Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.