PMID: 9543276May 16, 1998Paper

Adhesion molecule expression in the lung: a comparison between normal and diffuse interstitial lung disease

The European Respiratory Journal
A M SouthcottR M du Bois

Abstract

Cellular adhesion molecules are crucial determinants of the migration of immune effector cells to the tissues. In chronic inflammatory diseases, upregulation of the expression of these molecules may contribute to the persistent inflammatory process. The aim of this study was to determine whether there is evidence of adhesion molecule expression in chronically inflamed lung. Soluble adhesion molecules in bronchoalveolar lavage fluid (BALF) were measured by enzyme-linked immunoassay in 54 patients with chronic interstitial lung diseases and 16 normal controls. Adhesion molecule expression in fibrosing alveolitis (FA) lung and in control lung was assessed using immunohistology and reverse transcription-polymerase chain reaction (RT-PCR) amplification. Soluble intercellular adhesion molecule-1 (ICAM-1) was detected in all but two subjects. There was no difference in ICAM-1 concentration between disease groups and normal subjects. In contrast, soluble E-selectin was detected in 17 of the 70 subjects and was significantly associated with the presence of lung disease (p=0.0173). Furthermore, the presence of soluble E-selectin was associated with a raised lymphocyte percentage in BALF (p=0.0069). Soluble VCAM was only detected in five ...Continue Reading

Citations

Oct 5, 2001·Current Opinion in Pulmonary Medicine·J P LynchK Flaherty
May 12, 2000·American Journal of Respiratory and Critical Care Medicine·N SatoK Yamaguchi
Oct 27, 2004·American Journal of Respiratory and Critical Care Medicine·Marie D BurdickRobert M Strieter
Jul 11, 2000·Clinical and Experimental Immunology·M KasedaS Kohno
Sep 19, 2002·The Journal of Pathology·Annette M MüllerC James Kirkpatrick
Dec 23, 1999·Clinical Immunology : the Official Journal of the Clinical Immunology Society·M L TaylorB S Bochner
Jun 1, 1999·Current Opinion in Pediatrics·M S Howenstine, H Eigen

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