PMID: 7543837May 1, 1995Paper

Adhesion molecule expression on peripheral blood mononuclear cells in rheumatoid arthritis: positive correlation between the proportion of L-selectin and disease activity

Clinical Rheumatology
Y KurohoriS Kashiwazaki

Abstract

The expression of a series of adhesion molecules (the integrin family, the immunoglobulin superfamily, CD44 and the selectin family) on peripheral blood mononuclear cells (PBMC) from RA patients was investigated by flow-cytometry. L-Selectin (CD62L) in the selectin family was more significantly expressed on PBMC from RA patients as compared to those from normal controls. Further, RA patients exhibited a slight but significant increase of VLA-alpha 2 (CDw49b), p150,95 (CD11c), and VNR-beta (CD61) in the integrin family. The enhanced expression of L-selectin was positively correlated with disease activity. An increase in the proportion of L-selectin+CD4+ cells in PBMC from patients with RA and its clinical significance is reported.

References

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Citations

Jan 1, 1997·Rheumatology International·E M KittlK Bauer
Mar 30, 2000·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·P M KernM H Seegenschmiedt
Jul 28, 2016·Cell Reports·Fang DuMandy J McGeachy
Jan 22, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Steven P TreonEdward A Fox
Aug 23, 2020·International Journal of Molecular Sciences·Ching-Kun ChangDer-Yuan Chen

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