PMID: 28509452Jan 1, 2015Paper

Adhesion molecule JAM-A, its function and mechanism of epigenetic regulation

Advances in Gerontology = Uspekhi Gerontologii
B I KuznikM M Dyakonov

Abstract

The article represents evidence about structures, properties and functions of adhesion molecule JAM-A/1 belonging to JAM subfamily. This protein plays an important role in epithelial tight junction formation and immune function. Current article focuses on the role of JAM-A protein in pathogenesis associated to ageing: atherosclerosis, apoplexy, thrombosis, hypertension, ophthalmological pathology. We propose short peptides Lys-Glu, Lys-Glu-Asp, and Ala-Glu-Asp-Gly could influence on F11R gene expression that leads to recovery of JAM-A synthesis in cells.

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