Adhesion molecules and pancreatitis

Journal of Gastroenterology
Takeshi SatoShin Maeda

Abstract

Acute and chronic pancreatitises are gastrointestinal inflammatory diseases, the incidence of which is increasing worldwide. Most (~ 80%) acute pancreatitis (AP) patients have mild disease, and about 20% have severe disease, which causes multiple organ failure and has a high mortality rate. Chronic pancreatitis (CP) is characterized by chronic inflammation and destruction of normal pancreatic parenchyma, which leads to loss of exocrine and endocrine tissues. Patients with CP also have a higher incidence of pancreatic ductal adenocarcinoma. Although a number of factors are associated with the development and progression of AP and CP, the underlying mechanism is unclear. Adhesion molecules play important roles in cell migration, proliferation, and signal transduction, as well as in development and tissue repair. Loosening of cell-cell adhesion between pancreatic acinar cells and/or endothelial cells increases solute permeability, resulting in interstitial edema, which promotes inflammatory cell migration and disrupts tissue structure. Oxidative stress, which is one of the important pathogenesis of pancreatitis, leads to upregulation of adhesion molecules. Soluble adhesion molecules are reportedly involved in AP. In this review, w...Continue Reading

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Citations

Feb 6, 2020·International Journal of Molecular Sciences·Ana Ferrero-AndrésEmma Folch-Puy
Jan 28, 2020·American Journal of Physiology. Gastrointestinal and Liver Physiology·Irene Ramos-ÁlvarezRobert T Jensen
Apr 7, 2021·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Xufeng TaoGary Guishan Xiao
Jun 10, 2021·Mediators of Inflammation·Yinjie ZhangTien C Ko
Sep 18, 2021·Molecular and Cellular Biochemistry·Kamila Czubak-ProwizorMaria Swiatkowska

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