Adhesion molecules expression in noncrescentic acute post-streptococcal glomerulonephritis.

Journal of the American Society of Nephrology : JASN
M P RastaldiG D'Amico

Abstract

Clinicomorphological features of 11 cases of non-crescentic acute post-streptococcal glomerulonephritis (APSGN) were reviewed. Intraglomerular and interstitial leukocytes and their possible correlation with the adhesion molecules intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), and endothelial-leukocyte adhesion molecule-1 (ELAM-1/E-selectin) were investigated by an immunohistochemical method. Intraglomerular leukocytes were primarily granulocytes (11.4 +/- 10 cells/glomerular cross-section) and monocytes-macrophages (13.4 +/- 19.4 cells/glomerular cross-section). The granulocytes outnumbered monocytes-macrophages in 7 of 11 specimens. The number of intraglomerular leukocytes correlated with proteinuria at the time of renal biopsy. Intraglomerular ICAM-1 staining was strongly positive in all biopsies, especially when intraglomerular monocytes-macrophages prevailed. Expression of intraglomerular VCAM-1 and E-selectin in diseased kidneys did not differ from that in normal kidneys. Interstitial leukocytes were primarily monocytes-macrophages (158.9 +/- 96.8 cells/mm2) and T lymphocytes (102.2 +/- 63.9 cells/mm2). The number of interstitial leukocytes, especially monocytes-macrophages, correla...Continue Reading

Citations

Feb 19, 2000·Scandinavian Journal of Infectious Diseases·A NordstrandS E Holm
Oct 29, 2000·Journal of the American Society of Nephrology : JASN·Maria Pia RastaldiGiuseppe D'Amico
Jan 12, 2002·Kidney International·Shi-Xuan WangHarry Holthöfer
Jun 26, 2002·Kidney International·Maria P RastaldiGiuseppe D'Amico
Jul 9, 2002·Clinical and Experimental Immunology·F W K Tam
Mar 8, 2007·Kidney International·B Rodríguez-Iturbe, S Batsford
Mar 29, 2001·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·S HisanoS Takebayashi
Jul 18, 2009·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Holger HägeleHans-Joachim Anders

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