PMID: 9421612Jan 9, 1998Paper

Adhesion molecules in haemopoiesis

Baillière's Clinical Haematology
P J SimmonsA C Zannettino

Abstract

In the adult mammal, haemopoiesis is restricted to the extravascular compartment of the bone marrow (BM) where primitive haemopoietic stem cells (HSC) and their clonogenic progeny develop in intimate contiguity with a heterogeneous population of stromal cells that comprise the haemopoietic micro-environment (HM). Although the importance of cellular interactions between primitive haemopoietic progenitor cells (HPC) and marrow stromal cells is well established, precise definition of the nature of many of these interactions at the molecular level is lacking and remains an objective of fundamental importance to understanding of haemopoietic regulation. Current data suggest that a wide variety of cell surface molecules representing several adhesion molecule superfamilies, including integrins, selectins, sialomucins and the immunoglobulin gene superfamily, are involved in supporting cell-cell and cell-extracellular matrix (ECM) interactions. These diverse CAM-ligand interactions, rather than simply serving to initiate and maintain contact between HPC and stromal cells and ECM components, also have an additional, more direct role in controlling the growth and development of primitive haemopoietic cells.

References

Jul 1, 1992·The Journal of Cell Biology·K L MooreR P McEver
Aug 1, 1992·The Journal of Clinical Investigation·J TeixidóP Anklesaria
Jun 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·B ArdmanD E Staunton
Nov 21, 1991·Nature·Y RosensteinS J Burakoff
Feb 28, 1991·Nature·L J PickerE C Butcher
Jul 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·M J PolleyJ C Paulson
Jul 1, 1991·The Journal of Cell Biology·G S KansasT F Tedder
Jan 1, 1991·The Journal of Clinical Investigation·M RosemblattL Coulombel
Aug 2, 1990·Nature·T A Springer
Jan 1, 1991·The Journal of Clinical Investigation·E Ruoslahti
Mar 1, 1991·The Journal of Experimental Medicine·K MiyakeP W Kincade
Jun 1, 1991·The Journal of Experimental Medicine·F PillerM Fukuda
Nov 1, 1990·British Journal of Haematology·D SoligoG Lambertenghi Deliliers
Dec 1, 1989·Current Opinion in Cell Biology·J T Gallagher
Feb 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·A PallantJ G Frelinger
Jan 1, 1989·Annual Review of Immunology·P W KincadeJ M Gimble
Sep 1, 1988·British Journal of Haematology·M Y Gordon
Aug 1, 1985·Journal of Clinical Pathology·J T ReillyB A McVerry
Sep 1, 1983·American Journal of Hematology·M Tavassoli, A Friedenstein
Jan 1, 1982·British Journal of Haematology·S A Bentley
Jan 1, 1982·Journal of Cellular Physiology. Supplement·T M Dexter
Mar 1, 1981·The Journal of Cell Biology·R E Weiss, A H Reddi
Dec 16, 1993·Nature·Y Shimizu, S Shaw

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Citations

Apr 21, 1999·Experimental Hematology·J P Lévesque, P J Simmons
Jan 23, 1999·Current Opinion in Cell Biology·A D Whetton, E Spooncer
Feb 13, 2010·Stem Cells and Development·Menno ter HuurneRuurd Torensma
Oct 11, 2005·Annual Review of Cell and Developmental Biology·Linheng Li, Ting Xie
Mar 14, 2003·Stem Cells·Colin P McGuckinRuth Pettengell
May 9, 2008·Regenerative Medicine·Sean C BendallMickie Bhatia
Jun 15, 2010·Journal of Immunological Methods·Daniela BoehmMohamed Al-Rubeai
Aug 22, 2003·British Journal of Haematology·Karen A WhitingRuth Pettengell
Jul 20, 2006·British Journal of Haematology·David N Haylock, Susan K Nilsson
Aug 5, 2010·International Journal of Laboratory Hematology·B S Lam, Gregor B Adams
Jul 26, 2006·Experimental Hematology·Ingrid G Winkler, Jean-Pierre Lévesque
Feb 7, 2006·Experimental Hematology·Susan K NilssonIvan Bertoncello
Nov 30, 2006·Annals of the New York Academy of Sciences·Richard P Visconti, Roger R Markwald
Mar 22, 2001·British Journal of Haematology·J Y Chan, S M Watt
Mar 18, 2000·Leukemia & Lymphoma·S M Watt, J Y Chan
Jul 8, 2017·Artificial Cells, Nanomedicine, and Biotechnology·Seyed Hadi MousaviSeyed Javad Mowla
Jul 19, 2005·Nature Medicine·Jose A CancelasDavid A Williams
Nov 26, 1999·Pathology International·Y Sadahira, M Mori

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