PMID: 8964189Feb 1, 1996Paper

Adhesion molecules influencing atherosclerosis

Diabetes Research and Clinical Practice
D Tschoepe

Abstract

Life limiting diabetes heart problems predominantly result from accelerated thrombogenesis superimposed on a localized arterial vessel stenosis (atherothrombosis). The atherosclerotic process is a slowly progressing vitious cycle of self-amplifying cell-cell interactions. Initially, corpuscular blood elements, predominantly monocytes adhere to locally activated endothelial cells, before they convert into lipid laden macrophages. The proliferative response of media smooth muscle cells to foam cell derived mediators proceeds to the fibrous plaque where underlying subendothelial matrix material activates bypassing platelets. The new concept of adhesion molecules explains how streaming white blood cells can locally adhere to the endothelial cells (selectin mediated), become triggered, stick (integrin mediated) and consecutively transmigrate. P-Selectin rapidly appears in the outer membrane of activated endothelial cells and platelets. It serves as receptor for sialic acid containing oligosaccharides within the monocyte/PMN membrane. These cells adhere to locally activated endothelium (nondenuding injury) and form nidus for the further adherence of activated platelets. Later, when platelets become activated in response to nuding end...Continue Reading

References

Aug 12, 1976·The New England Journal of Medicine·R Ross, J A Glomset
Oct 1, 1992·The Journal of Clinical Investigation·M S MulliganP A Ward
Jan 23, 1992·The New England Journal of Medicine·V FusterJ H Chesebro
Sep 1, 1990·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·M E Rosenfeld, R Ross
Aug 1, 1987·The Journal of Clinical Investigation·L K CurtissE F Plow
Jun 1, 1985·Annals of Internal Medicine·A I Schafer
Feb 20, 1986·The New England Journal of Medicine·R Ross
Jul 1, 1987·Klinische Wochenschrift·M M Landgraf-LeursR Landgraf
May 3, 1984·The New England Journal of Medicine·M J Davies, A Thomas
Feb 1, 1994·European Journal of Clinical Investigation·P RösenD Tschöpe
Jan 1, 1993·Gastroenterology·J Raud, L Lindbom
Aug 1, 1993·The Journal of Clinical Investigation·D E LorantG A Zimmerman
Sep 1, 1994·Cardiovascular Research·M L Entman, C W Smith
Jul 2, 1994·BMJ : British Medical Journal·E VartiainenP Jousilahti
Feb 1, 1994·The Journal of Clinical Investigation·G H van ZantenJ J Sixma
Jan 1, 1993·Seminars in Thrombosis and Hemostasis·D TschoepeF A Gries

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Citations

Aug 25, 2015·Toxicology and Applied Pharmacology·Sae-Kwang KuJong-Sup Bae
Nov 10, 2009·International Journal of Cardiology·Fernando RibeiroJosé Oliveira
Oct 9, 2014·Glycoconjugate Journal·Qianghong Pu, Chao Yu
Feb 28, 2001·Diabetes, Obesity & Metabolism·L Drouet

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