PMID: 7542573Jul 1, 1995Paper

Adhesion molecules intercellular adhesion molecule-1 (ICAM-1), ICAM-3 and B7 are not expressed by epithelium in normal or inflamed colon

Clinical and Experimental Immunology
S BloomD P Jewell

Abstract

Adhesion molecules are involved in facilitating cell-mediated immune events. Because lymphocyte-epithelial cell interaction has been implicated in the pathogenesis of colonic inflammation, we analysed expression of a range of adhesion molecules on colonic epithelium in vitro and in vivo using flow cytometry, immunohistochemistry and in situ hybridization. Expression of ICAM-1 by cell lines HT29 and int407 was increased by proinflammatory cytokines interferon-gamma (IFN-gamma), tumour necrosis factor-alpha (TNF-alpha) and IL-1 but not by IL-6. Vascular cell adhesion molecule (VCAM) and E-selectin were not expressed. Immunohistochemistry using sections of inflamed colon from 16 patients with ulcerative colitis (UC), five patients with Crohn's disease (CD) and seven patients with normal colonoscopic biopsies, showed no expression of ICAM-1 on colonic epithelium. VCAM was seen in isolated lymphoid aggregates and E-selectin was expressed on endothelium. In situ hybridization showed no ICAM-1 or ICAM-3 mRNA in colonic epithelium. B7, the ligand for CD28, was not found on normal or inflamed colonic epithelium. The adhesion molecules ICAM-1, ICAM-3 and B7 are not involved in lymphocyte-epithelial cell interaction in the normal or infla...Continue Reading

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Citations

Jul 2, 1998·Clinical and Experimental Immunology·F A ArosaD N Posnett
Jan 1, 1997·Springer Seminars in Immunopathology·L LefrançoisL Puddington
Jan 1, 1997·Springer Seminars in Immunopathology·P BrandtzaegJ Rugtveit
May 23, 2002·Annals of the New York Academy of Sciences·P E R Brandtzaeg
Mar 1, 2000·Molecular Pathology : MP·P J Kilshaw
Jun 5, 2003·Clinical and Experimental Immunology·E C Ebert
Jun 24, 2017·Middle East Journal of Digestive Diseases·Shahram Nemati, Shahram Teimourian
Oct 16, 1999·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·A C LazarisP S Davaris
Apr 1, 1997·Immunological Reviews·A M Mowat, J L Viney
Jun 30, 1998·International Journal of Cancer. Journal International Du Cancer·A C DiederichsenA C Ostenhom
Mar 3, 1998·Nutrition Reviews·P Brandtzaeg
Mar 17, 2009·Clinical and Experimental Immunology·D OmagariK Komiyama
Apr 17, 2019·Digestive Diseases and Sciences·Franziska DurchscheinRudolf Schicho
Sep 24, 2020·Immunology·Cornelia HeubergerKevin Joseph Maloy
Jun 1, 2005·Microbes and Infection·Veerle SnoeckEric Cox

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