Adhesion molecules (VCAM-1 and ICAM-1) and C-reactive protein in women with history of preeclampsia

Acta Obstetricia Et Gynecologica Scandinavica
Ana PortelinhaIrene Rebelo

Abstract

Several studies suggest that women with previous preeclampsia (PE) are at increased risk of cardiovascular disease (CVD). We examined circulating concentrations of adhesion molecules and C-reactive protein (CRP), markers for endothelial and inflammatory reactions, in addition to blood pressure and anthropometric measurements in 58 women with a history of PE and 49 control women with no pathology associated to pregnancy. Soluble adhesion molecules were measured by standard commercial ELISA methods and plasma CRP levels by automated enzymatic assays. Systolic and diastolic blood pressures and waist-to-hip ratios were significantly higher in women with history of PE than in control group. There were no significant differences in circulating levels of sICAM-1, sVCAM-1 and CRP in the study population. Women with a history of PE do not have a persistent inflammatory state that could induce overexpression of these molecules, which was supported by normal levels of CRP. The study supports the existence of common risk factors for PE and CVD, namely obesity and hypertension.

Citations

Jun 16, 2010·Archives of Gynecology and Obstetrics·Imran A SiddiquiHanan M F Al Kadri
Apr 4, 2013·Biomarkers in Medicine·Imran A SiddiquiWaleed Tamimi
Mar 19, 2014·American Journal of Obstetrics and Gynecology·Sanne VisserChristianne J M de Groot
Jul 12, 2011·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Dan MihuCarmen Mihaela Mihu
Aug 13, 2010·Hypertension in Pregnancy : Official Journal of the International Society for the Study of Hypertension in Pregnancy·Hilary S GammillUNKNOWN Eunice Kennedy Shriver National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network, Bethe

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