Adhesion of binary giant vesicles containing negative spontaneous curvature lipids induced by phase separation.

The European Physical Journal. E, Soft Matter
Y SakumaS Komura

Abstract

We report the adhesion of binary giant vesicles composed of two types of phospholipids, one has negative spontaneous curvature which tends to bend toward the head group and the other has zero spontaneous curvature. In a homogeneous one-phase region, the giant vesicles do not adhere to each other, whereas in a coexisting two-phase region, the giant vesicles show adhesion. A fluorescence microscope observation reveals that the adhesion takes place through the domains rich in phospholipids having negative spontaneous curvature. We propose a phase separation induced hemifusion model where two apposed monolayers of adjacent vesicles are hemifused in order to reduce the bending energy of monolayers with negative spontaneous curvature and the boundary energy between the domains and matrix. We provide a strong evidence for the hemifusion model by lipid transfer experiments.

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Citations

Aug 13, 2013·The European Physical Journal. E, Soft Matter·U Jelerčič, P Ziherl
Mar 5, 2015·Life·Yuka Sakuma, Masayuki Imai
Mar 10, 2012·Current Opinion in Structural Biology·Wataru ShinodaMichael L Klein
Jul 21, 2010·Biophysical Journal·Yuka SakumaMasayuki Imai
Nov 23, 2018·Journal of the Royal Society, Interface·Nathan E BarlowOscar Ces
Jun 29, 2011·Journal of Physics. Condensed Matter : an Institute of Physics Journal·Takashi TaniguchiMasayuki Imai
Jan 1, 2014·Biophysics·Kei FujiwaraShin-Ichiro M Nomura
Jan 15, 2016·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Hiroki HimenoMasahiro Takagi
Apr 4, 2014·Soft Matter·Shuhei Kawamoto, Wataru Shinoda
Mar 21, 2018·Scientific Reports·Dayinta L PerrierPouyan E Boukany
Dec 21, 2011·Physical Review Letters·Yuka Sakuma, Masayuki Imai
Jan 15, 2011·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Miho YanagisawaTakashi Taniguchi
May 18, 2021·Computational and Structural Biotechnology Journal·Adriano CaliariTetsuya Yomo

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