Adhesion of Epstein-Barr virus-positive natural killer cell lines to cultured endothelial cells stimulated with inflammatory cytokines

Clinical and Experimental Immunology
Hiroyuki KannoT Sawai

Abstract

Chronic active Epstein-Barr virus (EBV) infection (CAEBV) is characterized by chronic recurrent infectious mononucleosis-like symptoms. Approximately one-fourth of CAEBV patients develop vascular lesions with infiltration of EBV-positive lymphoid cells. Furthermore, EBV-positive natural killer (NK)/T cell lymphomas often exhibit angiocentric or angiodestructive lesions. These suggest an affinity of EBV-positive NK/T cells to vascular components. In this study, we evaluated the expression of adhesion molecules and cytokines in EBV-positive NK lymphoma cell lines, SNK1 and SNK6, and examined the role of cytokines in the interaction between NK cell lines and endothelial cells. SNKs expressed intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) at much higher levels than those in EBV-negative T cell lines. SNKs produced the larger amount of tumour necrosis factor (TNF)-alpha, which caused increased expression of ICAM-1 and VCAM-1 in cultured human endothelial cells, than that from EBV-negative T cell lines. Furthermore, SNKs exhibited increased adhesion to cultured endothelial cells stimulated with TNF-alpha or interleukin (IL)-1beta, and the pretreatment of cytokine-stimulated endothelial cells...Continue Reading

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Citations

Jun 23, 2009·Journal of the American Academy of Dermatology·Chieko ShimuraHiroo Yokozeki
Jan 7, 2010·The American Journal of the Medical Sciences·John R HessNeil G Haycocks
Sep 14, 2012·Neurological Research·Sandra Morovic, Paolo Zamboni
Mar 27, 2015·Pediatrics International : Official Journal of the Japan Pediatric Society·Yutaka FukudaMitsuaki Hosoya
Dec 23, 2016·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Kohei KanoNaoyuki Hasebe
May 7, 2009·Current Opinion in Neurology

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