PMID: 7539623Apr 1, 1995Paper

Adhesion of flowing leucocytes to immobilized platelets

British Journal of Haematology
Patricia F Lalor, G B Nash

Abstract

Adhesion of neutrophils, lymphocytes and promyelocytic HL60 cells was compared in a flow-based model in which a monolayer of activated platelets formed the adhesive substrate. Each type of leucocyte formed P-selectin-mediated rolling attachments on the platelet surface under physiologically relevant flow conditions. Lymphocytes adhered less, and HL60 in similar numbers, compared to neutrophils, whereas the lymphocytes and HL60 cells rolled much more rapidly. Sulphated, sialylated saccharide(s) were implicated as ligand(s) for P-selectin for all leucocytes, but L-selectin (borne by neutrophils and lymphocytes, but not HL60 cells) appears to be a major presenter of ligand for neutrophils alone. T cells enriched from peripheral blood lymphocytes adhered in greater numbers than B cells. Differentiation of HL60 cells to neutrophil-like cells (induced by DMSO) caused cell volume to decrease and surface expression of integrin adhesion molecules to increase, but only a small percentage of cells were converted to an L-selectin-bearing phenotype. Differentiated cells showed evidence of stabilization of adhesion with increasing stress and a marked reduction in rolling velocity. These studies indicate that cell differentiation may be accom...Continue Reading

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Citations

Nov 14, 2000·Arteriosclerosis, Thrombosis, and Vascular Biology·M J Eppihimer, R G Schaub
Aug 11, 2001·Arteriosclerosis, Thrombosis, and Vascular Biology·C SkilbeckG B Nash
Mar 8, 2003·American Journal of Physiology. Heart and Circulatory Physiology·Katherine B Abbitt, Gerard B Nash
Dec 20, 2007·Journal of Thrombosis and Haemostasis : JTH·A C Ma, P Kubes
Dec 22, 2012·American Journal of Physiology. Gastrointestinal and Liver Physiology·Patricia F LalorDavid H Adams
Mar 1, 2013·Thrombosis and Haemostasis·Nailin Li
Nov 14, 2001·American Journal of Physiology. Gastrointestinal and Liver Physiology·J W SalterD N Granger
Oct 29, 1998·Critical Reviews in Clinical Laboratory Sciences·J D CavenaghS M Kelsey
Jan 17, 2008·Journal of Leukocyte Biology·Nailin Li
Apr 26, 2006·Journal of Thrombosis and Haemostasis : JTH·N LiP Hjemdahl
Jun 16, 2018·Arteriosclerosis, Thrombosis, and Vascular Biology·Angélica Salas-PerdomoAnna M Planas
Feb 13, 2001·British Journal of Haematology·K B Abbitt, G B Nash
Oct 22, 2002·American Journal of Physiology. Gastrointestinal and Liver Physiology·Janice RussellD Neil Granger
Nov 4, 2010·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Shantel A VitalD Neil Granger
Jul 20, 2004·British Journal of Haematology·Christopher A SkilbeckGerard B Nash
Mar 5, 2003·Arteriosclerosis, Thrombosis, and Vascular Biology·Anitaben Tailor, D Neil Granger
Jun 14, 2021·Korean Journal of Ophthalmology : KJO·Volkan YeterElif Kiliç Kan
Nov 5, 1997·Kidney International·C SegawaH Yokoyama

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