Adhesion of Staphylococcus epidermidis to biomaterials is inhibited by fibronectin and albumin.

Journal of Biomedical Materials Research. Part a
J C LinnesJ D Bryers

Abstract

Decades of contradictory results have obscured the exact role of adsorbed fibronectin in the adhesion of the bacterium, Staphylococcus epidermidis, to biomaterials. Here, the ability of adsorbed fibronectin (FN) or bovine serum albumin (BSA) to modulate S. epidermidis adhesion to various biomaterials is reported. FN or BSA was adsorbed in increasing surface densities up to saturated monolayer coverage onto various common biomaterials, including poly(ethylene terephthalate), fluorinated ethylene propylene, poly(ether urethane), silicone, and borosilicate glass. Despite the wide range of surface characteristics represented, adsorption isotherms varied only subtly between materials for the two proteins considered. S. epidermidis adhesion to the various protein-coated biomaterials was quantified in a static-fluid batch adhesion assay. Although slight differences in overall adherent cell numbers were observed between the various protein-coated substrata, all materials exhibited significant dose-dependent decreases in S. epidermidis adhesion with increasing adsorption of either protein (FN, BSA) to all surfaces. Results here indicate that S. epidermidis adhesion to FN-coated surfaces is not a specific adhesion (i.e., receptor: ligand...Continue Reading

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Citations

Dec 3, 2014·Colloids and Surfaces. B, Biointerfaces·Li-Chong XuChristopher A Siedlecki
Dec 17, 2015·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Li-Chong Xu, Christopher A Siedlecki
Jun 21, 2013·Journal of Biomedical Materials Research. Part a·Chang YaoMatthew Hedrick
Oct 2, 2015·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Xuhong JiangXinmin Wang
Dec 14, 2017·Scientific Reports·Fabíola CostaM Cristina L Martins
Mar 31, 2015·Langmuir : the ACS Journal of Surfaces and Colloids·Thomas VanzieleghemJacques Mahillon
Sep 4, 2021·Materials Science & Engineering. C, Materials for Biological Applications·Jayanti MendhiYin Xiao

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