Adhesion of tumour-infiltrating lymphocytes to endothelium: a phenotypic and functional analysis

British Journal of Cancer
D H AdamsS Shaw

Abstract

Efficacy of cancer immunotherapy with cultured tumour-infiltrating lymphocytes (TILs) depends upon infused TILs migrating into tumour-bearing tissue, in which they mediate an anti-tumour response. For TILs to enter a tumour, they must first bind to tumour endothelium, and this process depends on TILs expressing and regulating the function of relevant cell-surface receptors. We analysed the cell-surface phenotype and endothelial binding of TILs cultured from human melanoma and compared them with peripheral blood T cells and with allostimulated T cells cultured under similar conditions. Compared with peripheral blood T cells, TILs expressed high levels of five integrins, two other adhesion molecules, including the skin homing molecule CLA, and several activation markers and showed markedly enhanced integrin-mediated adhesion to a dermal microvascular endothelial cell line in vitro. Compared with the allostimulated T cells, TILs expressed higher levels of the cutaneous lymphocyte antigen (CLA), the adhesion molecule CD31 and the activation markers CD30 and CD69, but lower levels of several other adhesion and activation molecules. These phenotypic and functional properties of TILs should have complex effects on their migration in v...Continue Reading

Citations

Jun 2, 2000·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·S CuzzocreaD Salvemini
Sep 24, 2004·International Journal of Cancer. Journal International Du Cancer·Piotr JachimczakUlrich Bogdahn
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Mar 5, 1999·Breast Cancer Research and Treatment·N LocopoG Gasparini
Sep 1, 2005·Angiogenesis·T W KokRicky N S Wong
Apr 25, 2012·Pathology Oncology Research : POR·Hajnalka JókaiPéter Holló
Mar 28, 2017·Laboratory Investigation; a Journal of Technical Methods and Pathology·Robert SacksteinSteven R Barthel
Jan 18, 2020·Expert Opinion on Biological Therapy·Alvise SernicolaMauro Alaibac

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