PMID: 8970580Nov 1, 1996Paper

Adhesion properties, intermediate filaments and malignant behaviour of head and neck squamous cell carcinoma cells in vitro

Clinical & Experimental Metastasis
A M TomsonM van der Werf

Abstract

This study compared phenotype and behaviour of seven head and neck squamous cell carcinoma (HNSCC) cell lines and normal epithelial cells. Indications were found that in HNSCC cells: 1) loss of the cell-cell adhesion molecule E-cadherin was correlated with loss of epithelioid cell morphology but not with loss of cell-cell cohesion; 2) reduced expression of the cell-cell adhesion molecule desmoglein was unrelated to cell shape or motility; 3) high expression of the cell-substrate adhesion molecule alpha 6 beta 4, a receptor for laminin, corresponded with epithelioid colony formation while, in our adhesion assay, low expression of alpha 6 beta 4 paradoxically coincided with an increased adhesion to laminin; 4) presence of vimentin intermediate filaments coincided with loss of anchorage dependency. We propose that by simultaneous downregulation of E-cadherin, replacement of alpha 6 beta 4 by an aberrant laminin receptor and co-expression of vimentin a malignant phenotype arises of spindle-shaped, motile, anchorage-independent HNSCC cells with enhanced laminin-binding capacity.

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Citations

Sep 10, 2014·BioMed Research International·Thian-Sze WongJimmy Yu-Wai Chan
Jan 25, 2002·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·G J Thomas, P M Speight
Mar 23, 2001·Pathology, Research and Practice·F PittellaM Takagi

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