Adhesion receptor expression by CD34+ cells from peripheral blood or bone marrow grafts: correlation with time to engraftment

Experimental Hematology
Jack GoldPamela S Becker

Abstract

This study was undertaken to define the pattern of cell adhesion receptor expression by the CD34+ progenitor cells from mobilized peripheral blood and bone marrow from normal and autologous donors, and to correlate the adhesion receptor profile with time to blood cell recovery for patients undergoing autologous transplant. Blood cell recovery was determined by absolute neutrophil count (> 500/microL), time to last red cell transfusion, and platelet count (> 50,000/microL and > 100,000/microL). The analysis for expression of adhesion receptors alphaL (CD11a), alpha2 (CD49b), alpha3 (CD49c), alpha4 (CD49d), alpha5 (CD49e), alpha6 (CD49f), beta1 (CD29), L-selectin (CD62L), ICAM-1 (CD54), PECAM-1 (CD31), HCAM (CD44), and P-selectin (CD62P) was performed by two-color flow cytometry. The Kruskal-Wallis test and Spearman's rank correlation were used for statistical analysis. Statistical analysis of adhesion expression by the CD34+ population for patients undergoing autologous transplant demonstrated that the higher percent expression of PECAM-1 correlated with longer time to platelet recovery (> 100,000/microL, p = 0.049). In contrast, the higher the percent expression of alpha6 (p = 0.013) and the increased density of expression of a...Continue Reading

References

Feb 1, 1990·The Journal of Experimental Medicine·K MiyakeP W Kincade
Sep 3, 1998·The Journal of Clinical Investigation·J MollP Herrlich
Apr 12, 2003·Current Opinion in Hematology·Thalia Papayannopoulou
Jul 13, 2004·Transfusion Medicine Reviews·Sherrill J Slichter
May 14, 2005·Blood·Tsvee LapidotOrit Kollet

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Citations

Sep 13, 2013·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·Ayhan DonmezNihal Gokmen
Sep 9, 2015·Stem Cell Research & Therapy·Yuxia YangJianyuan Luo
Apr 1, 2014·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·James D'RozarioDavid Owen

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