Abstract
Cell adhesion has an essential role in regulating metastasis, and loss of cell adhesion is a classic feature of invasion. There is currently a great deal of interest in the role of adhesion proteins and the antimetastatic protein nm23H1 in the progression of cancer. However, reports on the expression of these proteins in complete hydatidiform moles (CHMs) are limited. In the present study, expression of the adhesion molecules E-cadherin, P-cadherin, CD44, and CD44v6, and the antimetastatic protein nm23H1 was assessed in relation to the invasive potential of CHMs. This is the first report on the expression of these proteins in CHMs. Immunohistochemical assessment was carried out in CHMs (105 cases including 15 cases of invasive moles) and compared with that of gestational age-matched normal placentae (95 cases). The expression of the adhesion proteins ranged from mild to moderate intensity with a general down-regulation in the molar trophoblasts, the down-regulation in CD44 and CD44V6 being highly significant. No relation was, however, noticed with the invasiveness or the persistence of the disease. nm23H1 protein, on the other hand, was significantly down-regulated in the molar trophoblasts with none of the invasive lesions sho...Continue Reading
References
Mar 22, 1991·Science·M Takeichi
Apr 5, 1991·Cell·A LeoneP S Steeg
Jul 12, 1991·Cell·K VleminckxF van Roy
Apr 16, 1990·Biochemical and Biophysical Research Communications·N Kimura, N Shimada
Mar 1, 1988·Controlled Clinical Trials·F Bernstein
Apr 6, 1988·Journal of the National Cancer Institute·P S SteegM E Sobel
Jan 1, 1971·The Canadian Nurse·A D Nevill, M L Parkin
Jun 1, 1995·Gynecologic Oncology·C KainzH Koelbl
Sep 1, 1995·Oncology·M Uhl-SteidlO Dapunt
Apr 1, 1995·Experimental Cell Research·D LombardiG Tibursi
Jul 1, 1994·The Journal of Pathology·J A RoydsT J Stephenson
Sep 1, 1994·British Journal of Cancer·Y ShiN R Farid
Jul 1, 1993·The Journal of Cell Biology·M SalmiS Jalkanen
Jun 1, 1993·Seminars in Cell Biology·S J Fisher, C H Damsky
Jan 1, 1993·Advances in Immunology·J LesleyP W Kincade
May 1, 1993·The Journal of Cell Biology·C L WilliamsT J Halsey
May 1, 1993·British Journal of Cancer·A R KinsellaB A Taylor
Dec 1, 1995·British Journal of Cancer·G SliutzC Kainz
Jan 1, 1996·World Journal of Urology·M J Bussemakers, J A Schalken
Jan 1, 1997·Gynecologic Oncology·K ShimabukuroN Toyamo-Sorimachi
Feb 28, 1997·The Journal of Biological Chemistry·J M FreijeP S Steeg
Sep 1, 1996·Molecular Human Reproduction·R GoshenR Stern
Aug 1, 1997·Histopathology·M E Smith, M Pignatelli
Aug 29, 1998·Hormone Research·M Taga, H Suginami
Dec 2, 1998·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·H Z SongY Xiang
Dec 1, 1999·European Journal of Obstetrics, Gynecology, and Reproductive Biology·P BalaramV P Gangadharan
Apr 1, 1998·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·H Z SongY Xiang
Citations
May 1, 2009·Histochemistry and Cell Biology·Baohua ZhangHongmei Wang
Feb 11, 2010·Reproduction : the Official Journal of the Society for the Study of Fertility·Ke-Ming XieDa-Jin Li
Mar 1, 2012·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Ying WangLi-Ping Jin
Dec 20, 2015·Pathology Oncology Research : POR·Onur ErolCem Sezer
Aug 5, 2009·Clinical Genetics·R SlimN Agarwal
Jan 10, 2009·Placenta·J D AplinL K Harris
May 31, 2016·Journal of Biochemical and Molecular Toxicology·Jiajun WangYongxiang Yin
Feb 22, 2012·Chemotherapy·Tie-Zhong YiWen-Hua Tan
Apr 9, 2010·Virchows Archiv : an International Journal of Pathology·T Padma PriyaSuraksha Agrawal
Sep 26, 2006·Human Reproduction·Omer ErdenAli Cetin